S-adenosyl-L-methionine
Origin: A naturally occurring chemical in the body.
Dosage: Tablets; 600 mg to 1,200 mg daily for osteoarthritis; 1,600 mg daily for depression. Because of possible interactions, SAM-e should not be taken without doctor’s supervision.
Claims: Treats pain, stiffness and joint swelling; improves mobility; rebuilds cartilage and eases symptoms of osteoarthritis, fibromyalgia, bursitis, tendinitis, chronic low back pain and depression.
What we know: SAM-e is an effective anti-inflammatory and analgesic for people with osteoarthritis. Results may be felt in just one week. SAM-e works closely with vitamins B-12, B-6 and folate, so it is important to get enough of the B vitamins when taking this supplement.
Studies: Over the last two decades, multiple clinical trials involving thousands of people have shown SAM-e to improve joint health and treat osteoarthritis. It has been found to be equal to NSAIDs in clinical studies. Most of this research has been done in Europe, where SAM-e is sold as a drug. A double-blind study of 61 adults with knee osteoarthritis done in the U.S. shows that SAM-e had a slower onset of action but was as effective as celecoxib (Celebrex) in reducing pain and improving joint function. A 2002 analysis of 14 SAM-e studies showed it is effective for reducing pain and improving mobility in people with osteoarthritis.
High doses of SAM-e can cause flatulence, vomiting, diarrhea, headache and nausea. SAM-e may interact with antidepressive medications and should be avoided if you have bipolar disorder or are taking monoamine oxidase inhibitors (MAOIs). It may also worsen Parkinson’s disease.
If you experience insomnia or stomach upset cut your dosage in half and slowly add 200 mg a day until you get to a tolerable level.
It's also important to remember to take it on a completely empty stomach and not eat for a half hour after taking.