S-adenosyl-L-methionine
Origin: A naturally occurring chemical in the body.
Dosage: Tablets; 600 mg to 1,200 mg daily for osteoarthritis; 1,600 mg daily for depression. Because of possible interactions, SAM-e should not be taken without doctor’s supervision.
Claims: Treats pain, stiffness and joint swelling; improves mobility; rebuilds cartilage and eases symptoms of osteoarthritis, fibromyalgia, bursitis, tendinitis, chronic low back pain and depression.
What we know: SAM-e is an effective anti-inflammatory and analgesic for people with osteoarthritis. Results may be felt in just one week. SAM-e works closely with vitamins B-12, B-6 and folate, so it is important to get enough of the B vitamins when taking this supplement.
Studies: Over the last two decades, multiple clinical trials involving thousands of people have shown SAM-e to improve joint health and treat osteoarthritis. It has been found to be equal to NSAIDs in clinical studies. Most of this research has been done in Europe, where SAM-e is sold as a drug. A double-blind study of 61 adults with knee osteoarthritis done in the U.S. shows that SAM-e had a slower onset of action but was as effective as celecoxib (Celebrex) in reducing pain and improving joint function. A 2002 analysis of 14 SAM-e studies showed it is effective for reducing pain and improving mobility in people with osteoarthritis.
High doses of SAM-e can cause flatulence, vomiting, diarrhea, headache and nausea. SAM-e may interact with antidepressive medications and should be avoided if you have bipolar disorder or are taking monoamine oxidase inhibitors (MAOIs). It may also worsen Parkinson’s disease.
