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Treatments > Drug Guide > Types of Drugs > Drug Guide: Sjögren’s Medications
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Drug Guide: Sjögren’s Syndrome Medications

Dry mucous membranes caused by Sjögren’s syndrome elicits descriptions from patients like, “food tastes like paper” and “eyes feel gritty.” Sjögren’s syndrome can occur by itself or along with autoimmune conditions, such as lupus or rheumatoid arthritis. Just as joints and connective tissues can be attacked as part of the autoimmune condition, the moisture-producing glands also can be attacked.

The prescription medications available to treat dry eyes and dry mouth are listed in the Sjögren’s syndrome chart. The oral drugs listed here work internally to help your body produce more moisture in the mouth. The dry-eye treatments add moisture to the eye or suppress eye inflammation. A surgical procedure to block the tear ducts (punctal occlusion) is an option for severe cases of dry eyes. Other prescription medications, such as the DMARD hydroxychloroquine sulfate (Plaquenil), may be used to treat other manifestations.

Over-the-counter treatments are available, too. Sugar-free chewing gum and candies, mouth sprays and rinses can help moisten the mouth and lessen discomfort. Available in sprays, liquids and pretreated swabs, artificial saliva products are sold under a number of brand names, including Glandosane, Moi-Stir, MouthKote, Optimoist, Oralube, Salivart and Xero-Lube. These products should be applied directly to the tongue, gums and roof of the mouth, according to package directions. Although these products do not stimulate saliva production, they do provide temporary moisture and can be reapplied as needed.

Eye drops can be used as needed (up to four times per day if bottles contain preservatives) and are available without prescription. Artificial tears (hydroxypropyl cellulose drops) are also sold under a number of brand names, including Artificial Tears, Bion Tears, Gonak, Isopto Tears, Lacril, Nature’s Tears and Ocucoat. To use the tears, place one drop in each lower eyelid and then close eyes one or two minutes, so tears can absorb. As with artificial salivas, the benefits of artificial tears are temporary. They can be applied three or four times daily. Be sure to check specific directions on the product’s packaging.

Other measures you can take on your own include sipping water throughout the day, avoiding smoking and caffeine and talking with your doctor about any medications you may be taking that could be drying your mucous membranes.

Ruth Townsend
10 Dec 2011, 08:40
I have been trying to get low dose interferon alpha lozenges which have had very good results in several trials for improving dry eyes and dry mouth in Sjogren's. My immunologist has prescribed it but I am having problems finding a supplier.
Marge Douros
16 Nov 2011, 08:24
Reading comments from others who are experiencing similar physical problems is a boost. My one concern was that Splenda was mentioned as a sugar substitute. I would strongly suggest that anyone using this product research its ingredients and I believe they will be very surprised, though disappointed. For anyone, staying away from prepared foods with all the addititives and buying organic (if you can afford to buy at least some)would be more beneficial to your health. Our environment with its pollution and the food industry (we have to pay more because of the "attractive" packaging) I theorize, are major contributors to the health of U.S.A. citizens.
Jolene
01 Nov 2011, 13:53
In 1995 I was diagnosed with RA after a flare left me with very little function in my arms and legs. I had a wonderful Dr. that immediately got me started with the necessary medicines to calm down the disease. In 2002 I moved back home and ran into a friend that told me I had always had problems with my joints, and I have so I've probably had this disease all of my life. I have since been diagnosed with Osteo and Sjogrens. The RA has flared to my heart and lungs once but due to having an excellent RA Dr. I have been able to keep things under control most of the time. Find a reason to laugh everyday. Trust me it helps. Reduce stress as much as possible. Move, yes it is hard but it does help a lot.
Judi
21 Oct 2011, 09:44
I was recently diagnosed with sjogren's. I have been to many Dr.'s over the years, seeing specific doctors for separate issues and noone tied anything together. My blood test for SS was negative but due to my symptoms, my rheumatologist finally ordered a lip biopsy which was positive. This was the last test done after EMG testing, Brain MRI's and tons of blood work. I had my lower tear ducts plugged which has really helped my eyes. I also use restasis twice a day. I am going to try acupuncture to deal with pain, it has helped in the past. In addition, I have gastroparesis which was diag. 3 years ago. I have to be on a special diet. Was relieved I finally have a diagnosis and am not going crazy. On the other hand, it is disease that is no picnic. People have to be advocates for their own health. It is frustrating at times dealing with doctors who think they know everything. I first went to the dr. thinking I had SS and was told no and ran up $$ in bills looking for other causes. Guess this patient knew best.
Thankful to find this forum and others who can relate to this.
Good luck to all.
Karen Longhi
17 Oct 2011, 14:02
I was diagnosed several years ago (I'm 69) with Sjogren's, osteoarthritis, and hypothyroid. I take Meloxican for arthritis, Synthroid for Thyroid, and Salagen for dry mouth and eyes, along with moistuizing eye drops. I canalso take up to eight Tyleno a day , if need for pain. I have had been treated by a psychologist for stress. This helped a great deal. I have learned to manage stress through relaxation technics as well as self hypnosis. Stress is an enemy to those of us that have autoimmune diseases. Any one who has a doctor who believes their illness is all in their head needs to change doctors asap. Sleep is important (even with many pillows for comfort. Pay attention to diet--many good and bad foods have an effect on us within a short period of time. Exercise (don't moan) is also very important, but your exercise routine needs to be a personal one, not geared to a physically fit teenager. Water exercises are very beneficial, but even then, you have to be in charge. Feeling the best you can is your goal. Sorry for the rambling. Go have a cup of herbal tea, and think positive thoughts about your day. And don't be a victim of your illnesses or doctors. Smile and laugh as much as you can--even when you're hurting. I feel better now than I did twenty years ago. Looking forward to your comments.
kimberly wanner
09 Sep 2011, 09:35
I have sjogren's syndrome, osteoarthritis and hashimoto's thyroid. I am unable to take the cholinergics to treat the dry mouth. I have lost all my teeth due to the effects of Sjogren's syndrome. I have started using Biotene moisturizing spray and ACT floride rinse for dry mouth. This helps greatly. Baskin robbins make some very tasty sugar-free candy. Added benefit is that it is sweetened with Splenda. Watch the amount of caffeien and carbonation in your drinks. The carbonation and acid dries out an already dry mouth. ALso look on the Sjogren's syndrome website for more helpful hints.
Caroline Stevenson
23 Aug 2011, 09:52
I too have ra, oa, chronic fatigue, sjogrens, to name a few. I found using a cold vaporizer at night helps with dry mouth, as well as biotene gel. Good luck to you all.
Judy Murray
21 Jun 2011, 21:26
To help make saliva: Chew Orbit Gum -Mist. Still don't have anything that works 100% for eyes
Sherri D.
14 Jun 2011, 13:15
I was amazed to see that there are so many people with this disease, including myself. I use to be a postal letter carrier, I started having trouble with heavy legs and just walking up a flight of stairs at work, then it got so bad, it would also wind me. I do have allergies and asthma to boot, lucky me, oh well, it could be worse. Then, I went to a rheumatologist who did an ANA and CPK blood test and found that I had Sjogren's disease. For the past year, I had the worse fatigue of my life, trouble breathing and my arms/legs ache so badly and my hands/ankles/feet swell to where they look like they will burst. I am trying to find another RA doc to help me again, but it is hard, docs need to give a patient time to undertand and rest from these draining diseases... good luck to all...
Lisa Frances
20 May 2011, 22:23
To all of my fellow suffers how much do you hate to hear "You look good" or "You don't look sick" it must all be in your head?
I was diagnoised with Carpal Tunnel after typing for many hours at my place of employment I had to have both hands operated on but then I started to have all of these strange occurences & I never felt well until I was diagnoised with Fibromyalgia of course I had no idea what that was so I learned all that I could & was doing ok not good but then I started to get sicker then I was told that I had Systemic Lupus, Sjogrens, Cardiomyopthia, Mitral Valve Prolapse,& so on it seems like everytime I go to the Dr's they find something else I've had a # of surgeries not to mention all of the medications which have all of there side effects I don't about you but I'm sick of being sick!!!! but if I can offer any suggestions to you it would be find a good Dr.no matter how many you may have to see,go to a support group, learn all you can about your illness & educate those are clueless, learn to laugh at yourself & the crazy things you find yourself doing, you may also need to contact Social Securtiy/Disability in this case make sure you have a lawyer.
I wish you all the best & that you may find some peace& copability in your life- no one can live it for you.......
Patricia Sullivan
24 Apr 2011, 09:32
My eye dr just sent me for blood tests for Sjorgens and I will go on Monday. It this related to people of Sweedish inheritance? I had a hemorage in my right eye and they did a "tear test" my result was 2. Maculardegenration runs in my family and would like to know if Sjorgen's is related?

What other organs can be effected?

I had a spinal abcess 2 years ago and I also get urinary trac infections. Interesting? Yes very!
Judy Murray
20 Apr 2011, 00:15
I have RA, osteo,sjogren's, fibro, chronic fatigue, IB, hypoglycemia,hypothyroid and Addison's. I've experienced the symptoms and used the products you have. I also have the sloughing of skin or 'something' inside my mouth almost every morning. I don't have a fix for it......Just wanted you to know that you are not the only one who has this yucky stuff.
Barb Whitcomb
15 Dec 2010, 19:37
I was diagnsed with Sjorgren's Syndrome about a year ago. But I have been suffering with the symptoms of it for a few years now. But thanks to my regular doctor ordering the right tests and getting abnormal results of them, she referred me to a rheumotologist where he diagnosed me with the right disease. And after putting me on Evoxac and hydrochloriquine, my symptoms have calmed down and seem to be in control now. I still suffer from achy joints and a dry mouth, but I have recently been chewing biotene gum and that seems to help the dry mouth at least for a short time anyway. I really wish that I didn't suffer from this awful disease, but I guess it could be worse! I only hope that it doesn't progress too fast (at least faster than we can keep up!)I do think that it's a horrible disease, but hopefully with time and progress, they will be able to contine finding more and more drugs to control the symptoms or at least dimish the symptoms of it.........Barb Whitcomb (Lewes, DE 19958)
Millie
22 Nov 2010, 18:06
I just happened to check out this site. OMG! I can't believe none of my doctors have ever mentioned this as apart of fibromyalgia(or just something that is commonly occuring). I was diagnosed in "96" and have had to endure most of my pain alone. Even some of my doctors don't believe in "Fibro".... thankfully there are places like this that I can now find new info. Thank you all for sharing your trials and wins....
paulajo
16 Nov 2010, 22:19
I am hoping some of my mouth dryness will pass. My symptoms are intermittent. For about 6 mos. my eyes and mouth were "normal" and so now I'm thinking I'm really suffering. Wake up several times at night to lubricate mouth.

Good luck with your voice. Sometimes mine is so hoarse I just quit talking but I'm not a teacher....
suzy b
10 Nov 2010, 22:51
I too have wondered about the body temperature...mine ranges from 97.5 to 99.8. I still recommend the biotene..I use the tooth paste, the mouthwash and the liquid and even the gel. These can be purchased at places like target, walmart, walgreens, etc. I am right now having a big problem with the loss of my voice. apparantly disease related...but can't seem to find a way to get it back! still very hoarse...no pain or excessive phlegm..by the way, I am a teacher so I do talk a lot, and stress it daily...probably does not help. I have had to miss days of work because of this.
paulajo
09 Nov 2010, 21:22
Its always helpful to get tips from others. I was diagnosed about 10 years ago and have been on amodiaquine or Plaquenil. Switched from generic to name brand Plaquenil due to skin issues. Anyway, I need help with my mouth. It feels scalded a lot of the time, many sores, etc. I have a metal taste frequently. I am having more dryness at night and wake with cottonmouth. My parotid gland also swells frequently. Do any of the lozenges work most of the night? Does water taste weird sometimes. Also, does sjogrens cause our body temperature gauge to go haywire?
suzy b
09 Nov 2010, 21:02
I have been diagnosed with sjogrens for 5 years, have had it probably more like 10. I have the dry eyes and mouth, along with sore joints, faitgue, lung and digestive involvement. I take MTX, Plaquenil, lodine,restasis and singulair. The best tooth paste and oral care products I have found are biotene. They are a little bit more expensive, but they really help.
Dene
05 Nov 2010, 00:42
Yolanda,

I have sjogren's, ra, fibromyalgia, to just name a few. My sjogren's is systemic including my digestive tract and my lungs. I have read sjogren's and lupus, ra, etc. can cause lung problems. My lungs are very dry and I have alot of problems with them. I would talk to my dr. about it. There may be ways they can help you with this! Everyone is different with autoimmune diseases. Good luck to you!
Lex
21 Sep 2010, 16:49
Reading what everyone has commented on. I don't feel all alone with Sjogrens. I found out I had this 5 years ago, my hygenist suggested I have my dr. test me for it and I think I have had it over 10 years. I have tried Plaquenil, that didn't help. Right now I am on Prednisone and Methrotrexate. Also taking Ibprofen and now Tylenol for more joint pain. The roof of my mouth usually bleeds and gums very sore. My eye doctor put plugs in my tear ducts. I don't see anydifference. He did suggest Systane Ultra eye drops, seems to help better, eyes don't feel so gritty. Also told me to use the Systane oinment at night. Again that seems to help as well. The only problem I have is getting toothpaste that doesn't burn my tongue. Any ideas? Right now I am paying $10.00 for a little tube of toothpaste from the dentist. Also my hygentist suggested a retainer for upper and lower teeth at night with a solution to help save my teeth. That is my next step. Take care.
Leigh Ann
03 Aug 2010, 10:29
I have been treated for 6 years for Sjogren's and trial and error and balance is the best advice I can give and best I received. Evoxac is wonderful and I suggest it if you have not tried it, it takes about a month to adjust to. I also like the Imuran as I tried Methotrexate for a year and could not tolerate it and have a normal life. I have found that diet is helpful. Low sugar or low carb yogurt daily will be a lifesaver against yeast infections both female and mouth. Lots of watery fruits - cantelope etc help as snacks and avoiding anything breaded and bread helps. Basically all naturals nothing perserved and you will feel 50% better. I did not really buy into this until after 5 years and now I am so much better and feel good. Excercise - Yoga twice a week helps and a massage once or twice a month will aleviate join stiffness. Just my experience and make sure you have a great rhemotolgist. I never go more than 90 days without a visit and she can keep your levels consistent without you crashing.
Jody
20 Jul 2010, 15:01
I have only been diagnosed with Sjogren's for 2 years, but have actually been suffering for more than 20 years. Please don't let people forget that even with primary sjogren's that your symptoms are more than just dryness. I also have sore joints and fatigue that are awful. Besides salagen, plaquenil, restasis, singular (for the sinusitis that I also get due to sjogren's) I also have been trying Imuran. I feel ALMOST "normal" now, with periodic flareups. My rhuematologist is wonderful and I am so grateful for her persistance in me feeling better rather than accepting the fatigue as normal. Please keep searching when you don't feel well!
Barb
04 Jul 2010, 23:39
About a month ago my tongue felt like it was thicker than usual. I then started having jaw pain. I realized that I was throwing my lower jaw forward, not sure why. But now my tongue gets really sore on the sides and seems to get larger after I eat. Is this something to do with sjogrens disease. I also have been diagnosed 26 years ago with celiac disease and last year with RA.
yolanda
22 Jun 2010, 23:09
hi i also have sjogrens and lupus and arthritis i have short of breath does anybody have that trouble also please let me know if u do so i can tell the dr. to check for it also thank you

connie tackett
09 Jun 2010, 19:33
I believe I have the worse case of sjogrens. my blood work is how they found that i had it. and i also have MS. but this sjogrens by far worse on me. I had my tear ducts plugged .which couldnt tell if helped but i will try anything. the dr has me on restasis,thera tears drops . i also take Doxycycline 5omg capsules 1 x day and i just started taking evening primrose capsules which i think are helping. i have tried evoxac and seem to make me so thirsty.i tried plaquenil and didnt see any help with it. i put a humidifier cool mist by honeywell and made a big difference. i can now open my eyes in morning without them being stuck together. and they are very quiet. find them on amazon very cheap.best thing i ever bought. have one in my living room to. i going to read up more on those bio tears. it gets overwhelming at times that I want to give up. it helps to read im not the only one who suffers with this.

my dry mouth no help in site.. my mouth sloughs off the roof and sides and my tongue will bleed. cant eat anything acidic, ketchup, mustard, hot sause, salad dressings,lemons will tear my mouth up. the lemons has made my tongue bleed.i go to dentist constanly because my fillings keep coming out because my mouth so dry. i will try some of the suggestions for the saliva sure and mouth sprays see if it helps. the corner of my mouth crack and i constantly keep vaseline lip therapy on them. it gets hard to talk sometime my mouth gets so dry. its so embarrassing. sometime i feel doomed. I hope some of this info helps someone else who having these issues and doesnt understand. also my glands swell up in my cheeks and i look like a chipmunk. and they are painfull.
Daisy
04 Jun 2010, 11:20
I had the lip test for sorjens and was put on meds. One had so many side effects that I
had to stop it but I do use the evoxac and it
seems to help with the dry eyes and also the mouth. Mouth is very dry at night. I use hard tack candy at night.
sheila caldwell
01 Jun 2010, 11:30
thank you all for your hints on helping, my dryness still here, been here for about 3-4 years now. i do not smoke anymore, but have hard candy to compensate for cigs. that helps some, but my tongue is so coated, i have to scrape it 4 or 5 times every morn. and my nose keeps building up dry mucous all day long. if anyone can help, would appreciate it, the drs. don't seem too interested. thank you
Virginia
10 May 2010, 14:42
To Sheila C.

I would definately have a lip biopsy done to determine it you have SS. Good Luck
Ann Z
28 Mar 2010, 22:52
Has anyone else with Sjogrens had the problem of sloughing of the mucosa inside the cheeks (both sides). I have Fibromyalgia and my DR thinks that with the dry eyes and mouth, I very likely have
Sjogrens as well. He isn't sure if the cheek sloughing is part of it. I haven't read that anyone else has that. I would appreciate any comments.
Carol Grady
17 Feb 2010, 13:34
There is a warning which I discovered for Salagen users....it's not for use if you have asthma and I do. My Doctor never checked that out....good thing I did. I also use a new oral spray called Rain to moisten my mouth especially at night. During the day sugar free gum works best. I've tried different lubricant eye drops but always return to my favorite "Refresh Plus" for sensitive eyes. Saline spray works great for keeping nostrils moist. I've been doing all this for about 27 years and have become use to the regimen.
gloria
02 Feb 2010, 12:09
To:
Sheila Caldwell in reponse to your non dignosis please have a lip biopsy if you haven't already to detect sjogrens S.
I had no antibodies show up twice in my blood tests but had slighly elevated crp and sed rate so we did the biopsy and it showed mild inflammation of the salivary gland the dr said it pointed to sjogrens so I could now get a prescription for plaquenil which hopefully will help. You have the same symptoms i have, i originally was diagnosed with burning mouth syndrome through an oral medicine specialist because of the burning i had too. You don't have the burning so....
Maybe you should check that out. Hope you find relief. I chew gum, drink water, eye drops, nose spray, and now plaquencil too soon to say if it will help. i used evoxac b4 the SS diagnosis but it didn't help me.

All the best,

Gloria



lois George
17 Nov 2009, 14:11
Have any of you had your B3 levels checked. Simple to add this test when you are having blood work done. But if you have never had it done, I would go now to get it checked. Your blood level should be in the 50's. Check out The Vitamin D Council. Google can find it for you.

Extremely important
Shari
16 Nov 2009, 18:28
Salagen has helped both my eyes and mouth. I rinse w/Biotene, occasionally chew sugar-free gum. Salagen is very expensive even in generic (Evoxac $225 for 90 capsules, 3 per day). I have also had punctal occlusion for my lower tear ducts and that helped. Every day includes eye drops. It helps to drink water and I find that summer heat causes more dryness.
SHEILA CALDWELL
20 Oct 2009, 19:59
I HAVE DRY EYES, DRY MOUTH, AND DRY NOSE. I WAS TESTED FOR SJOGREN'S AND WAS TOLD I DON'T HAVE IT, BUT CAN'T SEEM TO GET TO THE BOTTOM OF WHAT I DO HAVE. THIS HAS BEEN GOING ON FOR ABOUT 3 YEARS, AND IS DRIVING ME CRAZY, ESPECIALLY MY MOUTH. IF ANYONE HAS ANY SUGGESTIONS AS TO WHAT IT MIGHT B OR HOW OR WHO TO SEE TO REMEDY IT, WOULD B GREATLY APPRECIATED, THANK YOU
K Wittal
23 Aug 2009, 13:56
I use Bio Tears, very good product.
mary
20 Aug 2009, 09:55
I tried Salagen for years and it worked for me. I know it was expensive but my pharmacist has informed me that it now has a generic.
Ariviste
25 Jul 2009, 18:33
A good mouth lubricant that can be carried in the purse is a spray called Oasis. It temporarily moistens the mouth and can be quietly used without anyone knowing. An ointment that is very good for night use is Muro 128 which goes in the eyes at bedtime. It can be found sometimes on the drug counter with the eye drops and sometimes you have to ask the pharmacist for it, but it doesn't require a prescription. It was suggested by my ophthalmologist and keeps you from having to get up in the night to use drops.
Tiffany
12 Jul 2009, 21:58
Dear B. Mckibbin,

YES...I use Salivasure. My pharmacy carries it. It is about $8.50 a packett. If that is a better price let me know and perhaps we can work out something where I can help you get it. I know the horror of dry mouth. Also....the Salagen is a waste of money, huh? I was going to look into that drug.
B. McKibbin
21 May 2009, 13:35
In cooperation with my dentist, I was diagnosed with Sjogrens Syndrome several years ago and was prescribed a very expensive drug called Salagen. Later looking for an alternative I found a supplement (lozenges) manufactured by Scandinavian Formulas Inc. called SalivaSure. I have only been able to find it on the internet and a company called VitaCost seems to have the best price. The primary active ingredient is xylitol. Cost is about 1/10th that of Salagen.

A product for Dry Eye called Thera Tears Nutrition an Omega 3 supplement seems to help. I have been able to find it at Walgreen's, or by going direct to the company.
anil karn
11 May 2009, 00:10
i require details of drug today magzine

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