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Symptoms > Arthritis Symptoms By Body Part > The Knee > Injections and Procedures
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Injections and Procedures for Knee Pain

When oral medications do not relieve knee pain, but you're not to the point of pursuing knee surgery, one of the following injections or procedures may help.

Hyaluronic acid supplements – Although not technically medications, these substances are injected into knee joints to supplement naturally occurring hyaluronic acid. In healthy joints hyaluronic acid acts as a shock absorber and lubricant, allowing joints to move smoothly over each other. However, the acid appears to break down in people with osteoarthritis. Injecting it into a joint may lessen pain and inflammation. The injections are given weekly for three or five weeks, depending on the product (examples are Synvisc and Hyalgan). A small amount of joint fluid is removed first to make room for the hyaluronic acid.

Corticosteroid Injections – Doctors sometimes inject corticosteroids directly into the knee joint for quick relief of pain and inflammation. Their benefits may last anywhere from a few days to more than six months. While the injections bring targeted relief to the joint and lack many of the side effects of oral corticosteroid medications, they are not without risks. Repeated knee injections may actually contribute to cartilage breakdown. For that reason your doctor will likely put a limit on the number of injections you can receive.

Read a report from the British Medical Journal on corticosteroid injections for knee osteoarthritis. 

Arthrocentesis – Also called joint fluid aspiration, arthrocentesis is removal of joint fluid through a hollow needle inserted into the joint space of the knee. Although the purpose of removing joint fluid from the knee is usually so that it can be tested in the lab, removing excess fluid can also quickly ease pain and swelling. Often after withdrawing fluid, doctors use the same puncture site where the fluid was removed to inject a corticosteroid preparation and/or anesthetic into the knee joint to further relieve pain and inflammation.

Robin Thomson
24 Aug 2011, 10:08
Over the years I've had more and more trouble with my knees. I 've had a couple of cortisone injections and that gave relief for some months. This week I had my first injection of hylagan. Unlike the cortisone injections, this injection was very painful and the knee continued to be sore the following day. I don’t relish the thought of four more of these injections. Am I being a wimp or is this pain a sign something isn’t right here?
Della
02 Dec 2010, 07:03
I have Rheumatoid Arthritis, have had it about 14 years. Enbrel has been a miracle drug for me, along with Arava now and numerous other meds. Celebrex relieves my knee pain more than anything so far. My question is: Is it possible Synvisc injections could relieve the pain in my knees? It is advertised for OA, the damage from OA and RA are different so I would like to know if anyone has had good results with knee pain caused by RA? I have learned to keep searching for relief! Thanks Very Much, Della
Mark Lee
23 Nov 2010, 20:27
The war on drugs was never meant to be a war on pain! I suffer from Hidden Adult Onset Cystic Fibrosis. This could affect many more than was once thought. I cannot absorb the amino acids that produce natural pain relief, my body has no capacity to achieve this. If not for long acting narcotics I would have no quality of life. If you aren't getting relief get help. To allow someone to leave a Dr.'s office in pain is criminal, unethical, and FDA mandated. I have all of the symptoms of severe arthritic pain, but the voodoo and hallucinogen/amphetamine relatives like Cymbalta do not work. Be proactive in your pain, narcotics know no ceiling and no limits if used correctly and not sparsly!
Barbara
15 Oct 2010, 23:24
Hi
I went through 2 rounds of Hyalgan in my left knee and once in my right. I have to honestly say that it has helped tremendously! Prior to my having these injections I was getting physical therapy and anti-inflammatory meds (Mobic), which did help, but I did not want to remain dependent on oral medications. The Hyalgan is administered in 5 weekly injections every 6 months. All I can say from my experience that it is most definitely worth a try, especially if it will help in living pain free, increase your mobility (including steps!!!) and holding off surgery.
barb
17 Sep 2010, 04:57
Hi
I went to the Surgeon the other day thought I was ready for a Knee replacement,I chickened out!!!!! I was upset with my self because i need to have it done. So what I decided to do is the synveic injections again .they do help and maybe I will be emotionally ready early next year.
Will look for exercise program,I just have to keep going. Sorry I took the Dr's time but the surgery I have to be ready for it.
Keep your spirits up!!!!!
Vickie
09 Sep 2010, 21:18
Just about a year ago my knees where able to carry me. Now I can hardly walk 50 feet. I have had synvisc injection about 4 weeks ago and rehab. The orthopedic dr wants to do total knee on both knees. They said my used to be good knee has a syst on the main artery on the back of the knee and I injuried it about 3 months ago just turning a certain way I could not put weight on it for couple days but they said it has to do with the arthritis my other knee was injuried years ago with cartilage tear was repaired but ligament was never repaired by dr. I am 57 years old overweight what can I do to avoid surgery Please Help
laura egli
07 Sep 2010, 21:50
knees! Hyaluronic acid made me walk again.
Injected in both knees, and worked. Surgeons are somewhat, and sometimes negative for obvious reasons. Also suggest exercises in water regularly. I need help and will be glad to help others. Tell me how painful was the aftermath of knee replacement, or how successful.
ac silva
03 Sep 2010, 12:34
I fell playing tennis and tore my miniscus.

Going up or down stairs or getting up from the floor gives me great difficulty,

Would synvisc injections help?
oscar a herrera
03 Sep 2010, 05:06
I need help I have arthritis in my righ knee I lost 75 percent of my cartilage and to young to have knee replacement(43 year old). please send me any information of any treatment available. thank you
Marsha
24 Aug 2010, 19:19
I had a Synvisc-One shot 2 months ago and have had a good deal of relief from the knee pain from osteoarthritis. I know it takes some time to take affect, but it seems to work. Way less pain and I still do everything I did before - a bit slower and more cautious, but I am still feeling better for having the shot.

The shot is a bit painful for a minute or 2, but then it takes a couple of weeks to help and a bit of inflammation above the knee, but ice packs and ibuprofen help. Good luck!
ARLENE ROMAS
24 Aug 2010, 07:18
I NEED SOME HELP. I DO NOT WANT A OPERATION ON MY KNEE ACHES. I AM 90 YERS OLD. WHAT DO I DO
THANKS PLEASE HHELP

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