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Nutrition and Weight Loss > Vitamin and Mineral Guide > Vitamin Guide > Vitamin & Mineral Guide: Vitamin B-12
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Vitamin & Mineral Guide: Vitamin B-12

Helps make red blood cells, nerve cells and genetic material; converts folate to its active form. 

How Much: RDA = 2.4 mcg.

Too Much: UL not determined.

Too Little: Vitamin B-12 converts folate to its active form.  Too little B-12 can lead to a folate deficiency, resulting in pernicious anemia – malformed red blood cells causing fatigue, weakness, nausea, loss of appetite and weight loss.  Vitamin B-12 absorption declines with age; people age 50 and older should get most of their B-12 from fortified foods and supplements.

Foods: Found only in foods of animal origin; organ meats, egg yolks, clams and salmon. Fortified foods, such as cereal, pasta and bread, may contain synthetic versions, which actually are better absorbed.

Interactions: Antacids, drugs for indigestion and reflux disease, cholesterol lowering medication and the diabetes medication metformin.

Research Note: Maintaining healthy levels of vitamins B-12, B-6 and folic acid may protect bones by keeping blood levels of the amino acid homocysteine from getting too high.  High homocysteine levels affect the heart and are associated with cardiovascular disease.  They also may wreak havoc with the chemical bonds in bones.  A study shows supplementation with B-12, B-6 and folate decreased homocysteine in people taking sulfasalazine (Azulfidine) or methotrexate.

Shinnie Woods
29 Nov 2011, 09:43
Are 'night shade' veggies really should be avoided?
shrl
23 Jul 2010, 21:16
"supplementation with B-12, B-6 and folate decreased homocysteine in people taking sulfasalazine", is this true for people not on sulfasalazine also? Or does the drug have a special interaction with the supplements that helps to decrease homocysteine?
Kat
06 Aug 2009, 16:02
Hi,

As far as I know about vitamin supps reacting with other medications, I've been told that as long as you're not over doing the dosage, and taking it about 3-4 hours before or after your medication, you should be alright.

Hope this helps.
jae
27 May 2009, 08:55
I was reading the above comment... I, too, take an acid prohibitor. Protonix, once a day. Will you answer his question for all to see, or just direct to his e-mail? I would like to know the same answer.

I do not have Crohn's disease, but have wondered about the Protonix on a continual basis.
Ron Burch
25 May 2009, 16:55
I take two nexium a day, one in the morning before breakfast and one in the evening before dinner (1/2 hour or more before). Is it possible that I am not absorbing most B vitamins -- is see in interactions that reflux disease medicines may affect the absorption? I also take Reglan, another reflux disease medicine.

I also have Crohn's disease. For this I take 150 mg of Imuran.

What protocol should I follow with eating and the drugs to prevent Vitamin and mineral deficiencies?

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