Promotes healthy cell growth and reproduction; aids in the formation of DNA; regulates homocysteine levels.
How Much: RDA = 400 mcg for adults; 600 mcg for pregnant women. At least half of this intake (200 mcg) should come from fortified foods and supplements, which are better absorbed.
Too Much: UL = 1,000 mcg daily, or 1 mg. Doses higher than 1,500 mcg (1.5 mg) may cause minor discomfort, such as nausea, appetite loss and gas; and can mask a vitamin B-12 deficiency, resulting in nerve and brain damage. Folic acid may be prescribed at levels higher than the UL for people taking methotrexate.
Too Little: Increases the toxic effects of methotrexate; can increase homocysteine level. Low levels in pregnant women increase the risk of neural tube defects in their babies. Increased risk for certain cancers, depression, heart disease, anemia of chronic disease and Alzheimer’s disease.
Foods: Spinach, kale, collards, turnip greens, broccoli, garbanzo beans, lentils, peas, pinto beans, oranges and liver; fortified breads, cereals and juices.
Interactions: Antacids, alcohol, antibiotics, aspirin, carbamazepine (Tegretol), some cholesterol-lowering drugs, indomethacin (Indocin), oral contraceptives, methotrexate and sulfasalazine (Azulfidine).
Research Note: Methotrexate hinders the absorption of folate. However, if you take methotrexate for RA, you can use folate supplements safely. In a double-blind, placebo-controlled trial of more than 400 people with RA, folate supplements helped curb the side effects of methotrexate, including liver inflammation. A double-blind study published in the Journal of the American Medical Association reports stroke patients who took folate and vitamin B-12 has a lower risk of hip fracture compared with those taking placebo.
Leave a Comment