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Rheumatoid Arthritis Cases Appear to Rise

A recent study finds new diagnoses increase among women. Environmental factors may play a key role.

By Jennifer Davis

6/3/10 A new study has shown that for the first time in 40 years, the number of new cases of rheumatoid arthritis (RA) in American women appears to be on the rise.

Researchers say they don’t know exactly what’s behind the recent uptick – the number of new cases appears to have increased by about 2.5 percent between 1995 and 2007 – but they think environmental factors may be to blame.

“It was a statistically significant observation, which means it is unlikely to have occurred by chance alone,” explains lead author Sherine Gabriel, MD, a professor of medicine and epidemiology at the Mayo Clinic in Rochester, Minn.

For the study, published in the June issue of Arthritis & Rheumatism, Dr. Gabriel and her team sorted through medical records of 1,761 patients older than age 18 who had been diagnosed with arthritis. They found 466 of those patients were diagnosed with RA, and 69 percent of them were women. And while rates were increasing each year among women, they fell 0.5 percent a year among men.

This is an observational study, so while researchers were able to track the population over a long period of time, the data didn’t allow them to determine a cause for the difference in rates among women and men; and they don’t know exactly why more women are getting the inflammatory condition.

But they can make a few educated guesses about the increase.

“There are only two broad reasons for such a change – genetic or environmental,” Dr. Gabriel explains. “Genetic changes do not happen that quickly, as it takes many generations to change the gene pool. So it is much more plausible to assume an environmental factor.”

Scientists say there is evidence in published literature suggesting three environmental factors may increase the risk of RA.  The most obvious is cigarette smoking. Researchers say while fewer people in the U.S. are smoking than years past, women are stopping at a slower rate than men – which might account for the higher RA rates among women.

Ted Mikuls, MD, an associate professor in the division of rheumatology at the University of Nebraska Medical Center in Omaha, wrote an editorial accompanying the study stressing the importance of figuring out why RA is on the rise in women. He says there is strong data showing that smoking is one good possibility.

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Richard G Cronemeyer
22 Mar 2011, 05:39
Here I am again 6 months later/ NO Movemnt--- I have had 3 MRI , a Nueroligist and a eye ear nose MD . They all claim I have a deep sinus infection.Given Antibotics for the infection. Can not get back on Remicade or any other auto immune system drug untill the sinus infection is clear!!!!!Meanwhile not one of these MD has the answer to problem of my headaches????. MY Rheumatoligist wants to put me in a study for a new drug called Acumeria(spelling questionable) SO lets all do the Remicade jig ,sss ee you at the dance hall***********************************************Rich
Richard G..Cronemeyer
15 Jan 2011, 00:41
I recently was admitted to the ICU of our local conglomerate hospital with a respiratory arrest.
It was determined that I had walking pneumonia for approx.3 Wks, I was spitting up sputum (Heavy) felt Great till I went down on Oct 1st 2010
Point: Overheard the Md's saying the Remicade loweren my immune system, thus the onset of pneunomia, not considering the beef I have with the Metholtrexate. I spent 4 days pumped full of a Antibiotics Called Avello It cured me !!!!!
Dischared I was given a script for Avello (10)pills for 385.00 to finish me up ********
Now I have headaches Daily when I dont use Oxygen 24/7. Since the tubes were taken out of my wind pipe. I am 62 ,what do I do?
Scared to Death of Rhemacade/ not treating the Rhematoid Arthritus!!!!!!Stay away form those autoimmune suppressant drugs Is the only thing I have to Fight hid debilitating Deasese/ Signing off now Talked to much anyway, propally lost yourattion far back, have a GOOD LIFE !!!!!!!!!!! R.C.
S. E. Butler
12 Nov 2010, 00:28
In above message omitted the important fact that for the last few years chiropractic and acupuncture provide the best treatment for pain reduction and increased mobility. I cannot praise them highly enough.
S. E. Butler
12 Nov 2010, 00:24
I have had Sero-negative RA since early childhood, diagnosed at age 18, am 71 years old now. Of the many meds prescribed, the old gold salts, given in California by Dr. Peter Kelly, worked better than any. Went into remission and thrived. Moved to Texas and for 20 yrs. now on Arava and Celebrex w/hydrocodone for pain. These do not work nearly as well; more joints involved, mobility greatly reduced, disability increased, and pain constant. Dr. resists giving anything else.

No genetic involvement in my case and childbirth could not have triggered the onset of RA at age five. The massive amounts of food additives we consume and environmental pollution contribute heavily to the increase in RA patients. Studies have proven these two factors contribute or cause several dangerous diseases. Their involvement in RA will be proved as soon as politics and business are kept out of medicine disease.
Jen B
25 Aug 2010, 22:24
I have RA. I have been on Plaquenil for 8yrs, and various NSAIDS. I am doing great with only an occasional flare. I work full time as a Paramedic on the road. I have a physically strenuous job and often don't get a lot of sleep, but I have been very happy with my treatment, and have remained stable.
Patricia Amato
20 Jul 2010, 10:36
I have RA for about 8 yrs. My doctor wanted me to take Humira. I took 2 shots and ended up in the ER. Thought I was having a stroke. I read that RA could be caused by a virus and asked my doctor if I could start an antibiotic treatment. She insisted in the Humira and boo hooed my side affects. I now have a new rheumatoligist and have started an antibiotic treatment. No change yet but he said I might feel worse before I start to feel better. Fingers crossed.
Richard Cronemeyer
11 Jun 2010, 14:04
I have been on Remicade for 4 years !!!!!
I fortunately have had no side effects.
MY Insurance CO. BlueX, Blue shield refused to pay for the Remicade last year ! They told me" New Policy" and gave me the run around.
The Drug costs 1200.00 per infusion !
Fortunately and my point is that there are foundations that will pick up the co-payment
regardless of your income.
ASK your M.D about the organization he knows about.
What I worry about are the side effects that the readers have stated. Almost killed, was the common used defination of the side effect !!
I will get busy on my to Find Out <sincr\e my M.D says ther are None !!!!
Elsa S.
11 Jun 2010, 12:09
I have been living with RA for several years now and not taking any medication for it. My rheumatologist at first prescribed some off-label drugs but when I told him they don't seem to be working for me, he just gave up on me and said I would have to ask my primary care physician when I need meds for my pain. No other recommendations did he come up with. I just take Tylenol when the pain becomes unbearable. I've been prescribed some pain meds but they gave me stomach upset.
Denise M.
10 Jun 2010, 12:54
I was on Remicaide several years ago and it almost killed me too. I had severe chest pains, shortness of breath, severe chills and I kept telling my rheumatologist, but he didn't worry about. Then I had to go to the ER and was admitted. I had fluid aound my heart and three doctors, an infectious disease doctor, a cardiologist and a pulmonologist all said it was the Remicaide. Still my rheumatologist did not believe it. I decided to stop the drug and took months to get better. Was in hospital a couple more times. I realize this drug does help some people, but was not for me. Unfortunately, patients with RA do not have much choice but to try these drugs that could cause severe side effects. Some insurance's will cover acupuncture but not all and it does not work for all people but I believe, when you are in extreme pain, you will try almost anything.
Donna
10 Jun 2010, 10:15
I have always worked in schools and believe that mold has played a part in my RA. I do have a wonderful doctor and he has helped me find the right drugs for me. We do change them from time to time to make sure I can be the best that I can be living with RA.
monique
08 Jun 2010, 16:21
We have to be concerned about the prevailing treatment for RA. Remicaid nearly killed my mom. It's so expensive and deadly. Acupuncture and Chinese herbs have helped her build her immune system from Remicaid. She now has more enrgy. less pain and more mobility. She's not as depressed and her overall health has greatly imporved. Finally, not only did the drug nearly kill her, but it cost over $6500 every 6 weeks. We wonder why medicare is almost bankrupt. When she was on the drugs, her doctor sent her to new doctors for more drugs because of her new symptoms. This is no way to treat some one. Acupuncture must be included in insurnace policies - really!
Brian Taylor
05 Jun 2010, 20:23
I have always believed there is a genetic factor and a physical trigger that causes RA. The physical trigger in women can be childbirth. Check you numbers agains birth rates.

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