Research shows that fibrin, a protein normally involved in blood clotting, also plays an important role in the inflammatory response and development of rheumatoid arthritis
Fibrin deposits are a prominent feature of arthritic joints, and the protein appears to be a link between systems that control inflammation and bleeding within joints, according to a study funded by the Arthritis Foundation and published in the Journal of Clinical Investigation. Lead author Jay Degen, PhD, and his colleagues explain that in arthritic joints, the meshlike matrices formed by fibrin to create blood clots may control local activity of inflammatory cells as well as support inappropriate tissue reorganization.
The study suggests that inflammatory disease is driven by the inflammatory cells within fibrin matrices through a specific protein in the plasma membrane called aMB2. If that is so, developing medications that can stop the interaction between fibrin and aMB2 might help treat RA as well as many other inflammatory diseases, such as multiple sclerosis, says Degen, a researcher in developmental biology at Cincinnati Children’s Hospital.
Blood-Clotting Protein Linked to Rheumatoid Arthritis
Alee 15 Nov 2009, 15:27 |
| I'm 47 female and legs from knees down to ankels Hurt when deep pressure is done with just my fingers like i'm press a really bad burse but there no burses and at night if my husband moves to quik like a kick to the legs in that area it wake me to the ponit of pain with tears! WhY????????? |
Jazmine Coriano 12 Oct 2009, 14:25 |
| Hi everyone, I appreciate for all your feedback. I was told I had RA last year. This is the first time I was really looking for additional information about this because besides RA, I drink comadin for life for blood clotting. I am 27 years old and its a constant strugle and I am in denial. This had been very informative and I am going to find out what is triggering my RA.Thanks. |
Patricia 16 Aug 2009, 14:20 |
| I am on a lot of meds for RA and Fibromylgia and I feel bad all the time. I'm 67 yrs.old and I'm considering going off all my meds. I also have to take blood pressure meds and beta blocker. Had open heart surgery 5 yrs. ago and 3 heart ablasions. Would like some feed back about going off the meds. What is my alternative? |
D 21 Jul 2009, 08:35 |
| I have been with RA since 6 years now. I have found that bell peppers and
red meat are DEFINITE triggers for me. I read labels to make sure the bp's
are not in anything now (it's in a lot of stuff). I went from not being
able to walk or stand-to walking with no problems. I have flare ups at the
end of the day sometimes...but I am definitely trying to figure out what
works and doesn't! (and I've been off all the meds for 3 years-(it was
making me sick) I am all for trying new things to find some answers! Keep on...and let's find the fix! |
Jackie Carney 19 Jul 2009, 18:13 |
| I have been on LDN (Low Dose Naltrexone for about 3 months now. I am also
doing Prolotherapy along with nutrition. This has all helped tremendously
and I have been feeling great and do not take any of the suggested
medicines that RA doctors want you to go on. |
Lisa 17 Jul 2009, 11:13 |
| I was diagnosed with RA at age 27. Now I'm almost 47. It has been a struggle but I take Enbrel and it has really really helped. I don't have any side effects and I am alot less inflammed. I love it. But I am always open to new medications. |
Yvonne Patterson 17 Jul 2009, 08:46 |
| I am 56 and have had psoriatic arthritis since I was 27 yrs. old. Humira and methotrexate has been a big help to me. I can't help but think about the long term effects of these meds, but they are helping now. My fibro causes me a great amount of pain. Thank God that they are researching these disease and meds. I suffered for many years until Humira was discovered |
Anne 16 Jul 2009, 12:24 |
| I know the biggest thing that I omitted in my daily diet has been refined sugar and it has been for about 5 or 6 years now. I have RA but it has been dormant since giving up the refined sugar |
Yvonne Hodgdon 16 Jul 2009, 09:15 |
| I am on Kennert, the only medication I can take for y RA which I have had for about 8 years. I hope it is agreeing with me, I have had no ill effects, after maybe 3 or 4 months. I understand they are making an in haler for this medication, which would be a great thing. Any info on this new version? Thank You Yvonne Hodgdon 1063 Tremont Road Seal Cove, Maine 04674 |
Betsy 30 Apr 2009, 11:43 |
| Wouldn't that be great if it helped MS as well as RA. We have a very high incidence of MS in our part of the state for some reason. |
