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The Diabetes-Arthritis Connection

What do diabetes and arthritis have in common? Plenty

By Denise Lynn Mann and Donna Rae Siegfried

New research shows that people with diagnosed diabetes are nearly twice as likely to have arthritis, indicating a diabetes-arthritis connection. If you have both conditions, you probably take different treatments for them. You probably see different doctors for them. But the lifestyle changes you make for one may be good for the other. Eating smaller portions of healthy foods and walking daily, for instance, are important parts of treating diabetes; rheumatoid arthritis benefits from the same activities.

Diabetes occurs when the body does not produce or use the hormone insulin sufficiently. Insulin shuttles glucose from foods into cells so it can be converted into energy. Without insulin, glucose remains in your blood (raising blood glucose levels), your cells create less energy and you feel fatigued.

What starts off as a hormonal problem can evolve into joint problems, in addition to the widely known cardiovascular problems.  

Diabetes causes musculoskeletal changes that lead to symptoms such as joint pain and stiffness; swelling; nodules under the skin, particularly in the fingers; tight, thickened skin; trigger finger; carpal tunnel syndrome; painful shoulders; and severely affected feet. After having had diabetes for several years, joint damage – called diabetic arthropathy – can occur.

Though they both share connections with diabetes, rheumatoid arthritis (RA) and osteoarthritis (OA) are related to the disease in different ways. Having arthritis does not mean you’ll develop diabetes, or vice versa, but taking good care of your health in response to one condition might mean staving off or minimizing the other. 

Autoimmunity and type 1 diabetes 

Type 1 diabetes is an autoimmune disease, as is rheumatoid arthritis. In people who have type 1 diabetes, the body attacks the pancreas, the organ where insulin is made, just as RA attacks the synovial tissue lining the joints. Inflammation is the common culprit.        

Levels of inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), which often are high in people with rheumatoid arthritis, also are increased in those with type 1 diabetes. A study of people who had type 1 diabetes for longer than five years shows an increase in tumor necrosis factor-alpha (TNF-a), another inflammatory marker often elevated in people with inflammatory forms of arthritis. Inhibiting TNF-a with drugs such as adalimumab (Humira), etanercept (Enbrel) and infliximab (Remicade) is the goal of treating arthritis and related conditions.

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Karen
23 Apr 2012, 21:30
I had severe arthitis in my knees and had a knee replacement several years before I was diagnosed diabetic. I know I wasn't diabetic very long before I was diagnosed because I I've been seeing my internist every six months for about five years for other reasons.
Cece
24 Mar 2012, 16:47
I'm not actually a person with arthritis, but my grandmother is and has severe pain in her trudge ankle where a scar was found 6 months ago. Can you advise what action should be taken next? She has a Doctor but has not received any medications for this.

Jill
05 Mar 2012, 15:36
I battled with depression, pre-diabetes, and now I have a diagnosis of ankolysing Spondilitis, (spinal arthritis) which can be crippling, at times, I have lived with this most of my life, and struggle at times to do the simplist things. People, in general are antagonistic and do not believe me when I do not and can not do things. So I do my own thing.
Dave
05 Mar 2012, 09:03
I am Type 2 diabetic ( 15 years) .Since last one week I have been observing stifness in my right hand little finger .( Dose not mov smootly as other fingers of hand)
Any advise
Brigitte Johnson
11 Nov 2011, 10:18
Hello, i found this information very interesting. I have a child that was diagnoised with Type1 @ the age of 11years old. prior to her diagnoises, she was having knee pain. The doctors have no idea whats wrong.
The first thing i thought of was Arthritis. So, i seached and found your link. Its very informative and now i can ask the Dr. if there can be a link between the two autoimmune diceases.

Sincerely,
BJ
Kallol Biswas
25 Oct 2011, 13:38
My mother is 65 years old and is suffering from diabetics since 1995. Recently she is under treatment on insulin.

Recently, we observe that her right side knee has developed some swelling and pain is being felt.

Please guide us in this regard so that we can take appropriate steps from further complications
Alex
29 Sep 2011, 19:08
Funnily enough I looked this up as I have a diabetic dog. He used to suffer from arthritis in his back, but then when he was diagnosed with Diabeties two years ago and put on tice daily injections of insulin, he has never had problems with his Arthritis since!
seema
20 Sep 2011, 02:15
I am 42 years old lady. I have been suffering from severe backache for the last 13 years. doctor has dignosed it as soft tissue rhemotism of connective tissue disorder plus extreme lack of calcium. Now arthritis has grown in each and every joint. my wrists, elbows, shoulders and now recently feet joints always pain. I have also developed diabetes type 2 for the last one year. My Hb Aic was 7.5 in the month of march'11 which was diagnosed for the first time. I have also ibs and stomach erosions due to medication. now i have been taking pain killers and metformin 750 each day for diabetes and my fasting sugar levels remain upto 125 and 140 aftermeals and sometimes upto 165 after meals according to my diet. I remained always unable to do exercises due to extreme fatigue every time. i am overweight and my ionized calcium levels become 3.5 (normal range is 4.5 to 5.5). For the last two years i have been taking vitamin d3 injections during winter having six lacs potency. first year, i took 5. last year i took 10. doctor has advised me to take 12 injections ( 6 lacs potency) during every winters. I feel a little bit better by taking injections upto June/July bu t after that my condition becomes worst. i am a working lady. and it becomes great difficult to do the sitting job from 9 to 5.
i always take nutritious diet but it does'nt work due to ibs problems and hyper acidity problems. another problem of mine is that i can not do yoga or pranayams due to filthy smells at my flat at ground floor and i am unable to go outside due to my job's timings. please suggest something for my problems if possible.
Michael Lowe
12 Sep 2011, 22:09
I am 48 yrs old, have had type one for 42 yrs. Over the last 4-5 yrs have had pain issues. I have two tears in my left knee, neen to two different surgeons was told we can go in but we will mostlikely not be able to fix it. Second surgeon tells me that I have severe osteo-arth in both knees. I go to pain management Dr that prescribes 40 mg Hydrcodone per day. My regular Dr tells me to keep going to this Dr. Pain has been hard to deal with walking is an issue some days. Shopping trips with the wife are very limited. However, I am not on dialysis nor am I going blind. You must be strong and have a strong faith. I have seen and heard of many type ones that are younger than me that have a lot more problems and are no longer able to work. I am not on the pump I take three sometimes four injections a day.
muralidhara.S
10 Sep 2011, 09:47
Dear Doctor,

I am suffering from diabeties from past 6 years, but recently i have changed my diet but foot joints are paining. I have the doubt that am i have been attacked by arthrities. Kindly tell me what is reason?

Muralidhara.S
mouledino
26 Jun 2011, 10:53
iam diabetic and arthritis doctor advice me gulococephang 500mg morning and evening and hakeem advice to mix vainegar through food iam feeling well
mahbub reza
29 Apr 2011, 11:20
i am a patient of diabetic and arthrities. but my my doctor gave me salfasalazine. napa extend .folic acid,comprid. but i dont fell better. where i can get real treatment? please help me oh the generous person.reza.mahbub@yahoo.com 01673912264. from Bangladesh
Edgar A. Diaz
10 Apr 2011, 16:47
I am a diabetes type 2 diagnosed with rheumatoid arthritis about two weeks ago. It is affecting my knees and fingers. My doctor has told me that due to diabetes condition, and that the only thing he can give me is "Glucosamine HCL" 500mg three times a day.

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