Expert: Daniel Clauw, MD, professor of medicine at the University of Michigan and executive director of the university’s Chronic Pain and Fatigue Research Center and the Center for the Advancement of Clinical Research
Q: The approval of pregabalin (Lyrica) for fibromyalgia has been hailed as an important advance. Why is that?
A: In approving Lyrica for fibromyalgia, the FDA has legitimized fibromyalgia as a real entity. The new approval may broaden the number of fibromyalgia patients for whom doctors will use Lyrica, meaning more people with chronic pain may find relief.
Q: Is there any way to avoid the negative side effects of Lyrica?
A: Many doctors suggest breaking the dose up so the lion's share is taken at night. If you are taking 300 mg a day, your doctor may suggest taking 100 mg in the morning and 200 mg at night, since it doesn’t really matter if you are tired or light-headed while you are sleeping.
Q: Is Lyrica the first of many new fibromyalgia treatments to come?
A: Two more new drugs may get nods for FDA approval in the next year. Two of the drugs showing benefit for people with fibromyalgia are members of a new class of drugs known as norepinephrine serotonin reuptake inhibitors (NSRIs). These drugs affect levels of two brain chemicals, norepinephrine and serotonin, which play a role in pain and mood. Milnacipran is one of those NSRIs. The other – duloxetine (Cymbalta) – is already prescribed off-label for fibromyalgia and has FDA approval for major depression, generalized anxiety disorder and nerve pain.
Q: How will having a treatment option that is specific to fibromyalgia improve treatment of the condition overall?
A: When we use drugs, exercise, cognitive behavior therapy and education, we can manage fibromyalgia in a significant number of patients, but unfortunately that's not what has been done in routine care. Many physicians haven’t known what to use to treat fibromyalgia. They’ll use non-steroidal anti-inflammatory drugs and opioids, but we know they don’t work well for fibromyalgia. Having a drug whose FDA-approved label indicates it is intended for the treatment of fibromyalgia takes away some of the guessing involved in treating this difficult-to-treat condition.


































Natural healthy food, herbs to help you rest. Herbs for pain and inflammation. Supplements for energy and mental alertness. Drugs won't heal or address any of these problems. Apple cider vinegar and lots of water. Baking soda. Drug companies don't sell them because they can't patent them.
Prayers for all who suffer with Fibro - God bless.
Lyrica has helped to relax the pain I have in my back and neck from degenerative arthritis as well.
I too was on Tramadol for a while and it didn't do anything. Then, Hydrocodone, which I no longer need to take because Lyrica seems to be working for me personally, along with my herbs. However, I don't take them at the same time.
I still have to limit what I do quite a bit or I will pay for it the next day. :) But this is the first time I've had any kind of pain relief really. I've had Fibromyalgia since 1996 and this is the only drug that has helped me so far.
I remain on a healthy diet, drink plenty of water and get plenty of fiber in my diet as well as some walking and a bit of gardening.
I wish it worked for others the same way it is working for me. I've only taken one 50MG. tablet today! It just shows us how unique everyone's system really is.
May everyone here experience some relief from your pain... ♥ I hear you.
e Petrone, her program helps w/my trigger points and I sleep much better after doing this. Thanks for listening.
Side effects have been a "drunk" feeling about 2 hrs after taking the pill during the day. Effects go away in 1-2 hours. I sleep very well; do not take the flexeril any longer.
I have gained maybe 3 lbs since May, but through diet and exercise I am staying even in weight.
Lyrica has been a wonder drug for my nerve pain, has helped with any fibro pain and helps me sleep. I feel lucky when I see the others negative side effects written here. I would not be too concerned with the weight gain if you are commited to an exercise program and eat healthy.
Be well!
It was very intertesting reading about lyrica and nerve pain..........
i am given by my doctor but i am scared after readiong side effects.it the moment i am 8 tramadols and 8 paracetamol plus twice daily 10 mg mst continus-.morphine
still i go through hell of nerve pain in my coccys and hip area..i wish there was something to cure nerve pain but without these scarey side effects,
with Fibromyalgia, you are now having bad Daily (Chronic) Headaces? Also, what about Constipation? I refused to take Lyrica mainly due to the weight gain. I
just cannot afford to gain any more weight
due to a very painful knee. I feel like
I am in a Fog most of the time. I cannot
puts words together while having a simple
conversation. I seem to have a lot of anxiety and depression because the overall
body pain is just too much someimes. Thank
God my husband has been there for me and
has truly been a Blessing. The only thing
I take is Ultram mainly for my horrible
headaches and Topamax which I have recently started back on. Massages (Deep Tissue) some Chiropractic care has been helping me a lot. I know I should excercise more but every since I had a Bunionectomy Surgery in 2008 for my Hammer Toe, I am still dealing with a lot of pain. I have found that people with Fibro. do not do very well with post surgerys. Thank you for listening, and I wish everyone the Best, God Bless!
I gained several pounds when I added Lyrica to the mix, but it seems to have leveled off there. I need to lose it - but the relative freedom from pain makes it worth it to me.
Several mentioned taking double or more the amount of Lyrica that I take and it doesn't work well - I wonder if smaller doses in combination with Cymbalta would work better? I've taken both by themselves, and for me, it takes both together towork.
My experience was that 1) I slept like I was floating on a cloud and awoke refreshed; 2) I gained about a pound a day, and 3) after a week it was not as effective, and I felt depressed during the day. My choices then were to increase the dose or stop, so I stopped. I scarcely slept at all the first night I went off the drug, but got back to a normal pattern of a few pretty good nights followed by up-and-down every hour or so.
Tylenol PM still most effective drug for me.
It worked okay for the Fibro, but it really wiped out my migraines.
I'm back to being in constant pain.
mona - it's the right medication if it helps.
I am sure, like me, you are tired of feeling like a guiney pig and wonder how they got the drugs approved for FMS?
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