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Conditions > Fibromyalgia > Fibromyalgia Treatment > Cymbalta Approved for Fibromyalgia
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Cymbalta Approved for Fibromyalgia

Cymbalta becomes second FDA approved drug for fibromyalgia

6/16/08 People with fibromyalgia who haven’t responded well to other treatments now have another option. Duloxetine HCl (Cymbalta) became the second fibromyalgia drug to be approved by the Food and Drug Administration (FDA) based on data from approximately 1,400 patients in five drug studies.

In clinical trials for patients with fibromyalgia, Cymbalta significantly eased pain. Those who were treated with 60 mg or 120 mg of the fibromyalgia drug daily experienced greater reductions in the severity of their pain one week after starting medication compared to those taking placebo. After three months, patients treated with Cymbalta showed significant reduction in pain as well as improvement in Patient's Global Impression of Improvement (PGI-I) scores – based on a questionnaire designed to measure how the patient has felt overall since beginning to take the medication – compared with patients taking placebo.

Cymbalta is the first in a class of medications called serotonin-norepinephrine reuptake inhibitors proven to reduce pain in people with fibromyalgia. Although its precise mechanism for pain relief is not well understood, experts believe it increases the activity of two naturally occurring substances, serotonin and norepinephrine, in the brain and spinal cord. The substances are believed to mediate mood and regulate pain perception.

Fibromyalgia is the second pain indication for Cymbalta. Previously, Duloxetine HCl received approval for diabetic peripheral neuropathic pain. It is also approved for the treatment of major depressive disorder and generalized anxiety disorder. 

In 2007, the anti-seizure medication pregablin (Lyrica) became the first FDA-approved fibromyalgia drug.

 

Susan
20 Nov 2011, 22:26
Gisele, Be very careful with Cymbalta. It worked for me at first too. I ended up on 120 mgs. I ended up with severe permanent painful muscle damage and pulmonary hypertension. There are many stories like mine. The numbers are growing very fast. I have been off for two years now and I wish fibro was the only thing I had to deal with now. You think fibro pain is bad. Muscle damage feels like someone is ripping the meat off a chicken bone. Nothing helps. PH is not fun either.

I'm truly sorry you have fibro. It's not easy, but I am now drug free and feel better for it. Take care.
Gisele
14 Nov 2011, 09:39
Am not one to write in but I have to let everyone know my experience. I've been finally diagnose having fibromalgya. My doctor wanted to rule out other problems that I might have. It got to the point where I had trouble walking. I just couldn't get away from the pain. I'm only 53 years old and didn't know how long I'll be able to live my life in constant pain. My doctor finally put me on 10 mg amitriptyline and 30 mg of Cymabalta. After days, I just couldn't beleive the pain being almost gone. I still felt stiffness in my upper back and neck but the rest of my body felt good. After 2 weeks he increased it to 60 mg. After a month, the pain started again so he increased it to 90 mg. After 4 days, I was back feeling good again. It's been a month now and am feeling great. It's good to try different things rather then take nothing and live in pain. Don't give up, you have to do something about it because fibro doesn't get better on it's own.
Leanne
16 Aug 2011, 22:52
Thanks to all of the comments regarding current pain medications. I have been experiencing a great deal of pain lately - osteo arthritis so bad some days I cannot walk well. I was thinking about asking my doctor about Cymbalta but think I will stick with my current regime of accupuncture and natural remedies even if they don't work all the time.
Susan
05 Aug 2011, 15:24
Nikki, If you are on facebook, go to the page called Cymbalta Withdrawal Horror Stories. You do not want to take Cymbalta. Take a look at the video. That is exactly what Cymbalta can do to you. It has done that to many many people. Google Cymbalta Martha Rosenberg. This is a drug that should never have been put on the market. It does a great deal of harm. BEWARE! Doctors do not tell you the whole story and some or most, for whatever reasons, will not tell you. Have you vitamin D level checked. Most fibro suffers have low D. It needs to be in the 60-80 range. The CWHS page has lots of good ideas about ways to cope with pain and not take meds. I've had fibro for 35 years and I've been through it all and I've been damaged by meds.
Nikki
04 Aug 2011, 11:32
I am 21 years old and was just diagnosed with fibro. My doctor told me to start taking 30mg cymbalta and in a week up it to 60mg. I'm very nervous taking this medication. I'm not really depressed, I just have been suffering from pain, fatigue, and headaches. After reading the comments I'm not sure what to do. Am i to young to take cymbalta? Advise please.
Thankyou
Susan
21 Apr 2011, 19:54
Here is a youtube video that pretty well sums up my life with Cymbalta.

http://www.youtube.com/watch?v=yeq4gSfMXdo

I hate for this to happen to anyone else.
And yet everyday someone else puts tha first pill in their mouth and swallows. It makes me want to cry.
miss vita m king
17 Mar 2011, 17:28
cymbalta,is something esle,i have taken alot of things,i have rheumatoid arthritis,they have a lot of drugs now.the cymbalta,doesn't help me that much,i told one doctor,i need more drugs,the pills were not helping.some people say that they help with this and that.what i have found,living overseas,and on the east coast,its the drug that older people take.everyone i talked to,and doctors visits,they were older people,40s and over.i have a 27 year old daughter my one and only,i would never want her to take that med.she is to young.i was 27,she is to young for that drug.i haven't had any side affects from it.and please,depression,you have that,just by being a Dam WOMAN THATS NORMAL.thats why the doctors,are the way that they are,they say THIS IS A WOMAN.and YES i LOVE BEING A WOMAN.and the older you get thats just how it is.along with your FYBROMYALGIA,and whatever esle you have.i am 48 yeaers old,as i said,when i was a little girl,the White WOMEN,use to KEEP THERE PILLS IN A PRETTY PILL BOX.one woman told me,that i would take those pills when i grew up.you will be a FULL GROWN WOMAN.she was so pretty,a line dress,and a bonnet,that cover half of her head,she was just so pretty.i said when i become a full grown woman,i am going to have pretty pills boxs,and wear those kinds of dress,and a bonnet,i dress that way anyway.thats why i was with THEM.and they open there pill,boxes,and cursed just like some of the men.i would say i am going to get marryed and have pretty pill boxes,just like them.(smile)they said i would,and a man with money.so i am saying woman,i am only talking about a womans body,they have been taking,pills,for depression,and pain,head aches for years.pretty pill boxes,and i am going look for me some.they do look pretty in my purse.and and a lot of woman get into depression,from having kids,thats what the doctors said.all of the stress on the body.and if you haven't ever had a baby be glad.and yes i love my one and only daughter to no end,i have always loved her,no matter what,my pain from,this horrble,thing that is going on with my body has never stopped that.some woman are not that way,they got like that after the birth,they had no control over that.it just happen,even back,in the 50s,60s,70s,80s,90s.and the cymbala is late,i don't know what they call the pills that they took back then,outside of nerve pills,and this and that.and life does go on,depression,pain and all.yes you can still laugh,and smile,and mean it.have a good loving relationship,with your mate.depression is nothing new,it has always been around,the men use to say,if someone said that woman is crying,they would say hell,she is a woman.even men knew what a woman was,men knew back then.lyrica,i have never taken that one.and people that,i ran into didn't talk about that one.it was all of the other pills,and the shots.they said that the shots,are something esle to.the after affect,i haven't had one,the doctors have asked me about them,but i have never had one.the east coast is research,captial,and overseas.the pills and the new machines,very very nice hosptials,and the very very nice rooms.the suite room,thats what i use to think when i was waiting on the doctor to come in.thats what my ex-fin.thought the suite room.well hell it should be,look at what you have.the rooms should be dam nice.and yes i love the east coast,and overseas,and how long are in the room,telling the doctor about the cymbalta,and how it is working.crusing sometimes.you don't have to be nice,hell you are in pain,if you are then thats how it is that day.opera music,jazz,country music,new wave,all that is good.and i have also,found that,for some people that cymbalta,takes away all of there feelings,i couldn't believe,but it is true.i haven't gone threw that,with that pill.i never took the pill like that.i never took it like i was taking,a happy pill.have you tryed the new marj.the doctors say that it works,and there patients said the same thing.the women were right,with the pretty pill bottles.everything they said back then was true,all of it.and keep in mind where you live,are you living where you want to live.that is very very important.thats why there husbands tryed to make sure they lived where they wanted to.they always tryed.where you live,is very important you need to be,in your place where ever you are,place as in,state,city town,island.and in whatever kind of house it is you want,apt,dupulex,condo,house,townhouse.cabin,boathouse.you need to be in what you want to be in,and in the right state.and they were all right about that.pretty pill bottles and a shot of vodka,or gin.a line dresses,and a half of a bonnet over there heads.and lets not forget the gloves,i love wearing thoses.it is a day in day out,job and it is a job.its called doing you.and no i don't work for a company,anymore,nor do i work for myself anymore.i work on myself now,and that is always a good thing,and yes i am going to find me some pretty pill bottles for my purse.the depression meds.and taking the other meds that you take,they are not taking you,you are taking them,thats how they get in your mouth.stay under a doctor,miss vita m. king,miss,not mrs,at this time,mrs.coming soon.
Jill Jones
16 Mar 2011, 06:36
I have been taking CYMBALTA for years for Depression. I hardly think it is helping my Fibromylasia.
Because I am a medication controlled Diabetic, I cannot take any Cortisone drugs. I also have degenerated discs in my back, so, I do take a combination of prescription pain medications. I am in a quandry as to what else to try. LYRICA has soooo many side effects. I am really leery about trying that.
What over te counter could possibly help?? And, you can forget about the Miracle pill ALEVE. What a joke.
Susan
28 Feb 2011, 14:28
Lynette, have her vit D level checked. It should be in the 60 to 70 range. Most doctors do not check this and most people with fibro have very low vit D levels. I also take magnesium, fish oil, B complex, B6, ginger, tumeric, and I try to stay away from sugar as much as possible. I do not drink any carbonated drinks. They all seem to increase my pain. I take my magnesium at night with calcium and vit d. I am on presciption vit D right now trying to get my level up. When my level is low, my pain is much worse. Most people will agree with me about that. I also take 5htp which increases the seritornin in your brain, which is also one of the things Cymbalta does, but without the nasty side effects. I do a lot of research on my own and have finally found a good doctor who will listen to me and work with me on more natural ways to cope with things. Most of these new drugs are not very safe. Dr. Oz had a doctor on his show that said to stay with the the older drugs and to avoid the newer drugs that had come out in the last ten years or so. I am very cautious now. I am very careful. Good luck to you and your daughter. If you are on facebook, there is a page called Cymbalta Withdawal Horror Stories that may interest you.
Lynette Kelly
28 Feb 2011, 11:03
Susan
Thank you for your input. I have noticed some of these side effects from 60mgs. I am not going to up the dosage, and am going to start looking for alternatives. This is for my 18 yr old daughter who is planning to go off to college in the fall. Do you, or anyone else have some alternatives that have worked for you?
Susan
25 Feb 2011, 19:21
Lynette, I took 120mgs for fibro and it was the biggest mistake of my life. It caused muscle stiffness in my leg that led to muscle damage. I also developed pulmonary hypertension while on this drug. This has aslo happened to other people while on this drug. This is a very, very hard drug to whithdraw from for a great many people. It took me 18 months to withdraw. My side effects were horrendous: I was hospitalized with atrial fib, I had extreme mood swings with two suicide attempts, joint pain, muscle stiffness and pain, vertigo, dizziness, brain zaps, feeling out of body, intense itching with blistering, abdonminal pain, vision changes, sugar cravings, weight gain, personality change, cracked root of molar from grinding teeth, and a trip to HELL for myself and my family. I reported this to the FDA and to Eli Llily. You can go on facebook and find others with the same stories and online you can find other threads where you will find people who have suffered from this drug. Most doctors only listen to what the drug reps and the drug company's tell them about the drugs they prescribe and we as patients need to do our own research. I learned the hard way and now I have a condition that is terminal.
Lynette
24 Feb 2011, 11:31
I understand that Cymbalta is only fda approved at 60mg for fibro. For any of you that take a larger dose (90 or 120)does your insurance pay for the larger dose (since its only approved at 60)?
susan
18 Jan 2011, 14:36
I was on Cymbalta (30) for only 1 month.I was supposed to go back and get more but the weather dampen my appointment. Finally after a week the doctor gave me (30's) for one more week then (60's) after that. The appointment was for rapid heart and dizziness. I feel that if I am on Cymbalta for another 6 months the outcome will be worse than the pain I had/have with arthritis and fiber. I have not taken the meds since I came back from the drs. Call me scared but knowledge is the best policy....and I cannot imagine the reprocuusions of taking such meds.Even my husband mentioned the fast moodiness while on the meds. Such a difference in me. Throwing things in a rage. THIS IS NOT NORMALLY ME!!!!
Susan
10 Jan 2011, 17:13
Patty, I don't think anyone here is bashing drug companies, etc., but when doctors and a drug have almost destroyed your life it makes a person either lay down and die or stand up and fight and I choose to stand up and fight. I feel that I should have been told about the side effects of Cymbalta and about the horrible withdrawal side effects. I was not. I have muscle damage in my leg and I suffer pain from that and now I have a disability from that along with my fibromyalgia. I am D*** angy about that. The only side effects I was told about were a little nausea, so take it with food. HA!! I just want everyone to be informed and to do their own research. Doctors, unfortunately sometimes only listen to the drug reps who are out to sell the drugs. I now use supplements, meditations, music, and massage therapy. I also exercise every day no matter how I feel. I am taking control of my life and no longer letting some doctor take control. A friend saw a recent picture of me and compared it to a picture of me while I was on Cymbalta and said I looked like I was ten years younger and much happier. I feel human again. Good Luck to all of you with fighting your pain. I still fight mine. By the way, have your Vit D level checked. Low Vit D makes my pain worse and I need to keep my level in the 60-80. Good Luck everyone in your journey.
Patty
06 Jan 2011, 07:28
Fellow Fibro sufferers,
No bashing here of any pharmaceutical company, or their medications, for what doesn't work for one, may work wonders for someone else, we are all different. God only know's, I have tried them all. Yes, at times I've felt much like the designated ginny pig, reporting for work. But, when you are desperate to feel better, for just one day, that's the chance we must take. I am currently taking 60 cymbalta and 60 XR Adderrall for the Fog that presents the inability to focus, it has helped me complete tasks. And I thank God, that I have a physician who threats me with respect, allows me to keep some self dignity, when asking for pain meds. I am convinced that without them, all the lyrica, cymbalta, etc., alone, would not do it for me. Be careful of inevitable stress in your life, eat well, get sleep, whenever, naps help, if you can get one. I sleep with a heating pad or microwavable heating bags, even in 90 degree weather. Acupuncture has helped me tremendously manage my pain, as does massages. Although very expensive and I know not everyone has the luxury of such services. If I cut down on Hair, nails and some grocery purchases, and instead put towards Acupt & massage- my days seem better. But all this being said, I must be honest, as much as I'd like to go back to work. I could not do that to any employer unless he or she knew the severity of flare ups that would keep me from doing the job that I was hired. How fair would that be? So for all you,to whom are fortunate enough to have understanding bosses, remember to thank them! Otherwise, you left at the mercy of Social Security Judges that will decide you fate. Thank God, for now I am able to still meet each morning with hope for a pain free day. If not, I know that things in my life could be a lot worse. Just look around and see what others deal with day in and day out! God Bless us all!
Dorline
04 Jan 2011, 12:50
I have Fibromyalgia, Osteoarthritis, Leukemia, etc. I was on Lyrica for about a year and it helped me so much with my pain then I started having muscle weakness,muscle twitching and severe muscle cramps. My dr. then tried me on Savella, it was awful I was given samples of it and wasn't told of the side effects which were the same as withdrawal symptoms, sweating, chills,anxiety,insomnia, i wanted to scream it was so bad.I finally had to decide for myself that it was the Savella and I quit taking it and went back to taking Neurontin until I could see my Dr.He then put me on Cymbalta. He said it would take about 3 weeks to start working after 1 1/2 weeks I was haveing the same side effects that I had with Savella.I stopped taking it and took Neurontin again and Meloxicam for my arthritis. I was hurting so bad all the time. in only a few hours I was begining to feel better, not so nervous and pain was much less. I am now trying to find something that will work for me before I go back to the Dr. I am really tired of taking these drugs that make the drug companies rich and all the while ruining so many peoples lives. I just want to take my pain meds and a good Arthritis med.I don't want to be used as a testing pot for drug companies anymore. You have to take control of your own treatment sometimes. just use good judgement and keep notes from day to day.I think that the reason why these drugs work for some people and not others is that they all are antidepressants and lots of us don't need some of the ingredients that are in these drugs. For myself I am not trying anymore "new" drugs for Fibromyalgia until they have been tested a lot more. I know that our Dr's should tell us the bad side effects so we know what is going on when it starts to happen to us and most of them don't.
Susan
15 Dec 2010, 14:12
I have posted before about my very bad experience with Cymbalta. I have recently been documented with muscle damage to my calf muscle resulting from Cymbalta use. I also developed pulmonary hypertension while on Cymbalta. I have been off Cymbalta for 14 months now and the withdrawal symptoms still are not completely over. I caution anyone on this drug to be very careful withdrawing. I weaned off and still was hospitalized with atrial fig, had extreme mood swings {with two suicide attempts}, joint pain, major clawing pain in calf and muscle stiffness and pain, vertigo, dizziness, headache, brain, zaps, feeling "out of body", intense itching with blistering, abdominal pain, vision changes, sugar cravings, weight gain, personalty changes, cracked root of molar from grinding teeth needing expensive implant, and months HeLL for myself and my family. If anyone else encounters problems with this or any other drug I encourage you to make a report to the FDA https://www.accessdata.fda.gov./scripts/medwatch.online.htm

Many doctors only know what drug reps tell them about drugs. I read that Eli Lilly made six billion dollars on Cymbalta last year.

I am sorry I ever took that first pill! It has changed my life forever.
Suzanne Carter
05 Dec 2010, 23:38
I was diagnosed with Fibromyalgia in 1996. After trying many medications that really didn't help, my PA put me on 50 MG of trazadone and 60 MG of Cymbalta. It was like someone had turned the light back on. I feel normal again and am able to work full time. My advice to anyone looking for relief is to not give up. Try whatever your Dr. thinks might work for you and if it doesn't, keep looking. And try to keep a positive attitude, I know that's what has helped me through my darkest days. God Bless!
Bev
22 Nov 2010, 14:07
I have read all the above testimonials, and am scared to death to take any RX, only pain meds. I do not see any response to the above questions. Can anyone respond? Do you have any medical personnel on your staff? I have tried Sevalla, and anti-inflams for FM. I had 10 days of 80% relief from the extreme pain, only to have it come back. Does FM come and go, settling in different body parts when it returns? Can anyone answer me? I am off meds for FM, only taking anti-inflams, and heavy pain meds, as needed.
Vicki
18 Nov 2010, 13:55
I've been taking Cymbalta for 3 years now. I think it must be a wonder drug. My fibromyalgia pain is almost gone completely. I used to suffer from sever depression and I now feel like a normal human being. I did go through a couple of tough weeks when I started mostly upset stomach but once I got through that I was fine and never have had any adverse effects.
Janetta Hitt
25 Sep 2010, 14:24
I have had fibromyalgia for 15 years. I also have ringing in the ears, that makes fall on a regular basis. I got a walker, and it helps, but when I walk just from the living room to my bedroom, I am exhausted and have to lay down for awhile. I have Spinal stenosis, pinched nerves in my neck and lower back. I had a procedure done on my back to try to separate the nerve from the muscle in my back. I worked for 32 years with a daycare for children in my home. I take Wellbutrin and Effexor, but my new doc wants me to stop them and start Cymbalta. I am afraid because of side effects.
Nancy
18 Sep 2010, 15:14
I've been taking Cymbalta for seven years. I started at 60 mg and my doctor increased the dosage to 90 mg last summer.

I have two questions. Do you take your meds two times a day, and if you do, at what times? Also, does Cymbalta make you tired?

Thanks,
Nancy
Vanessa
17 Aug 2010, 15:23
Since 1993 I've been diagnoised with Fibromyalgia. I've been on all kinds of meds. I can't remember when I was put on this medicine Topamax around 2003, but it took all my pain away. In 2004 my loving son passed away then my fiance created another tragedy the same day. Then I went on back on pain killers. Had to have a knee replacement. Went back on Topamax now I'm wenning off because it causes memory loss. It does help alot of people to lose weight tho. So take this info to your Dr.s
susan
22 Jul 2010, 15:34
I have suffered from fibro for 30 yrs was put on opiods, antidepresants, anticonvunsants, sleeping pills, you name it. These drugs almost killed me. The morhine caused me to get pulmonary hypertension, which is a progressivie terminal disease. The cymbalta caused permanent muscle damage to my leg and the withdrawal lasted for seven months. Now I am allowed threes tylenol a day for my pain, because I can not have anything that will supress my breathing. My pain was not relieved by these meds. and the doctors just told me to take more. It was not until I could not even stand up and take a shower because I could not breathe that I finally found a doctor who found out I had PH and said get off these drugs. Since then I have improved as fas as my PH goes. I deal with my pain with mediatation, supplements, massage therapy, water exercise, and a lot of positive thinking. Yes, I still have pain, but I no longer believe everything doctors tell me and I listen to my own body. I also watch my diet. No sugar. That really increases my pain. I urge everyone to research, research, reseach, and be you own advocate. There are good doctors out there, but there are also a lot of bad ones out there.
Josephine C.
10 Jul 2010, 16:26
Cymbalta, Paxil, Cipralex and other meds for fibromyalgia hurt my sensitive stomach and gave me acid reflux. Can anyone recommend something I can take that doesn't hurt my stomach?
Teddi
05 May 2010, 21:56
I am in extreme pain from 9 herniated discs, arthritis, fibromylgia, restless legs since i was 5, etc etc etc. Why do the drs give us so much grief about giving us this medication on time/ i need this on a regular basis. why do the drs and insurance companies want to see us suffer and be tortured with pain? i thought they took an oath to do no harm? where are there morals?why is this is so expensive we cannot buy it, i lost my job and health insurance due to my pain,. i am in extruciating pain and very MAD
\\\
Audrey
04 May 2010, 16:00
I have been taking Cymbalta 60 mg, 2 times daily for 1 year. Once a day worked to relieve the pain for about 6 hours but I wanted to stay active for the rest of the day. My doctor was more than happy to prescribe a second pill to keep me comfortable for the rest of the day. I have Multiple Schlerosis, severe neuropathy, arthritis, severe scoliosis and advanced multilevel degenerative disc disease, multilevel spinal stenosis, (history of 5 back surgeries) restless leg syndrome, etc. It was wonderful to find something that actually worked to help relieve the pain. I still take Neurontin 600mg 5-6 times daily, but have not had to take narcotic pain pills. I take Requip 4mg for the restless leg syndrome. I have not had any side effects from the Cymbalta. I am 72 years old and my weight is stable at 105 pounds.
Kim
04 May 2010, 15:28
Thanks to all the blog submitters. I just started 30 mg Cymbalta this week. My doctor told me about one of her patients came in crying for joy with the relief that it provided. Now I know the rest of the story and what to be on the look out for. My sleep hasn't improved, had diarrhea the first night/morning (improving), and have acquired smelly sweats. Performance in the gym, just holding my own-no improvement. Thank God for my massage therapist she kept me going before the diagnosis and we know why she has to work harder using deep tissue massage.
Trish B.
22 Apr 2010, 11:53
I was diagnosed with fibro/CFS complex 4 years ago. I also have DISH and OA and have stenosis and multiple bulging discs. I also suffer from chronic depression that became debilitating a number of years ago due to death of my sister and dad a few months apart. Between the depression and worsening of the other conditions I lost my job last year after 25 years.

I just started Cymbalta last week. My old anti-depressants stopped working. I talked with my doc about the side effects of Cymbalta and he said that I won't know until I try it. I told him I had heard nightmare stories about the drug...and he asked if I had been on the internet again. He said that most patients who have had problems with it was because the went off the drug cold turkey.

However, I will try it anyway even if it lessens my use of pain meds and helps with the depression and fatigue. I can't use anti-inflammatories because I have gastric ulcers and IBS. I think the fatigue is the worst symptom for me because I have always been a very active person.

My rheumatologist put be on Neurontin and a new anti-inflammatory called Arthotec. Arthotec was developed for people with GI systems like mine. It has an awful side-effect, it makes you very nauseous, even with food. He warned me it would do this, I tried it and then quit, but he wants me to continue. He also did shots in the skull and shoulders which helped for awhile.

So, my next plan of attack is the nutritional side, we'll see what happens!

Hang in there folks!
Faerie
13 Mar 2010, 02:09
I started taking 60 mg of Cymbalta on February 2. The first 5 days were a blur. I was a total zombie. At exactly three weeks I experienced a day without pain - the first that I can remember. Not only that but it totally deals with the excess adrenalin in my system from PTSD.

I've actually lost weight because I am so much more active now. My doctor sent me to physical therapy to learn some stretching exercises. She also gave me Celexa (anti-inflammatory) to help me adjust to the significantly higher activity level.

It's only been a few weeks since the Cymbalta kicked in but I feel like I have my life back.
Bonnie
23 Feb 2010, 17:22
I started Cymbalta in May 09 and it helped with the pain, depression and sleep within a week to 10 days. That dose was 60 MG daily. I had dry mouth as the only side effect, I could live with it. However, in July 09, the dry mouth went away and the pain increased and it seems that irritability and mood swings started again. My dr increased me to 90 MG daily and within 3 days I was back to myself, happier, sleeping better and reduction in pain and fatigue. Then I had rotator cuff surgery end of Sept 09, was off work until 1/4/2010, but went through the recovery period well, not requiring more than Vicodin for the 1st couple weeks post op. Now that I'm back to work, I'm feeling some days that the 90 MG may not be working as well. Am going to give it a couple more months in case it's just the end of the winter doldrums getting to me. I see where some are on 120 MG for Fibro, so I know there is room for change. Just keeping that as a last resort. I guess this Cymbalta has worked the best for me of anything I've tried, and since having FM for over 30 yrs, I've tried it all.
Linda
21 Feb 2010, 20:34
I was placed on Savella for a chronic pain problem I've had for more than 20 years. By day 3, I was pain free. However, I only tolerated Savella for 7 1/2 days. I had to get off because I began to sweat so profusely, I was wet 24/7, constantly changing out of my clothes. This is the worst side effect I've ever had, and now, a good three weeks after getting off of the drug, I'm sweating profusely again. I am SO AFRAID that Savella damaged my body in some way and that this may be a permanent condition. This is debilitating--I can't even leave the house and now I may be dealing with depression if this sweating problem doesn't stop. I can't even sleep because I'm soaked!
Norma
17 Feb 2010, 18:14
So how do you get answers from this site?
Norma
16 Feb 2010, 11:51
I was treated with cymbalta for about 7 months,it helped with my pain and seemed to work great, except for the weight gain. I talked to my Dr about it and was told it doesn't cause weight gain.(wrong gained thirty lbs). He put me on a tapper prescription and I have been completely off it now for several days. Even though I tapered slowly, I am having withdrawal symptoms that are very hard to deal with. dizzy and slightly nauseas.Pain is coming back but the drug s really scare me. i was on Lyrica before that but had to quit because or chest pain and racing heart. Anyone else have this experience?
Judy
25 Jan 2010, 19:59
Lorie and others, I have been taking Cymbalta for about 4 years. I did have a lot of pain and it seemed to come from my nerves and spinal cord. I also have the sweating but find that I itch constantly. I am 70 and have been active, not workout stuff but gardening, housework and crafts, for all my life.
I find the sweating a pain but I live most of the year in Florida and mostly use the 'humidity' as a disguise. lol I wish I could find a cure for the itching. I am wondering if an increase in dosage, I am on 60 mg once a day, would help. May check in with my DR and ask. Good luck to all. JUDY
susan cook
15 Jan 2010, 18:40
i started on cymbalta about 4 and a half weeks ago for fibromyalga and it has not helped yet. first 30 mg one a day for 3 weeks then 60 mg one a day for 2 weeks. i am now on 60 mg the 4th or 5th day. i am taking it for my muscle, tendons, and other arthtitis pain and tightness. i can sit down and the pain almost goes away instantly but when i get up the pain starts aching in my hip and my whole right leg. and the more i walk the worse the pain gets and it gets badddddd. i had a total hip replacement nov. 20, 2008 on my left hip and it does not hurt at all in fact my left hip and leg is perfectly painless. i will continue to take the cymbalta but i don't know yet.
Maureen Robertson
06 Jan 2010, 16:32
Hi everyone!
I was diagnosed with post viral fatigue syndrome after having shingles. I seem to be prone to the virus as I have had the chicken pox and ramsay hunt syndrome in the last 2 years.
possible immune problem but has never been discussed seriously with doctor.
Anyway the muscle pain, extreme stiffness, heavy body lethargy and total mental fog making it hard to thinks were predominant.
I also had stomach problems and now have IBS.
I had headaches for days on end. I had excessive sweating, mainly to the head. The breathlessness can be quite distressing, getting stuck on the stairs makes me feel like an old woman, I am only 45.
Some days I would lie in my bed after waking and not be able to move, my whole body felt numb. I was also a bit weepy at times, felt like I was losing control of my emotions.
Any form of activity would leave me feeling like I had been kicked repeatedly by a horse for about 4 days before the pain would ease of a bit.
Anyway my doctor put me on duloxitine to try and deal with the pain and because I was running to the toilet up to 27 times a day indicating bladder problems just to add to the fun!
Started on 80mg daily which made no difference to the pain. The sweating is a nightmare, but I lost half a stone because I just didn't feel hungry
To try and combat the pain and fatigue he upped my dose and I have now been on 120mg daily for 12 weeks and finally I am getting a bit of relief, I only go to toilet about 15 times now! The headaches are gone and the fatigue has lifted a little bit. The downside is the pain hasn't been relieved at all. I have gained weight as the dosage has gone up, 14stone now, was 11 1/2 before.
The seritonin has improved my mood though.
Still sweating at the drop of a hat, very slow on my feet with little stamina.
I have lived with the pain for 2 years now with no real pain relief out of a bottle.
I have to stop on the hill I live on 3 times to stop my out of control breathing, it is close to hyperventilating, bit scary!
The last time I saw the doc, he said he didn't know what to do with me so doesn't bode well.
having read the posts here, I think I will ask to be taken off duloxitine and put on a separate anti depressant and ask to be refered to urology for the water works.
I don't like being the weight I am now and still having the sweating, pain and stiffness, I see no point on staying on it.
candy
21 Dec 2009, 13:03
I went off the Cymbalta because of the side effects. Then the withdrawl was HORRIBLE. Brain zapping. 1 month off the meds, I now have terrable restless leg. It is also in my arms and it's all the time day and night. I just want to scream!!!! This is worse than the fibro pain. I have had 2 steroid shots one in my lower back and one in my neck. They have worked better than anything else I have tried.
Libby
07 Dec 2009, 13:31
I have been on 90mg of cymbalta for about a month now and my doctor is upping my dosage to 120mg/day: 60mg in the morning and 60mg in the afternoon. I want to know if there are any other depression/fibromyalgia sufferers out there taking such a dose and if it is helping them and if they are having any side effects with the dosage increase? eefktaking
Dorothy
16 Nov 2009, 13:53
This past week with the weather change, I could not move everything hurt, both fibro and RA flared up, I just stayed curled up in bed for 2 days. My family just closes the door and leaves me alone, my son understands, my husband can't stand to see me in bed, that hurts even more. The pain gets to where the meds don't even work. Then of course depression sets in because I hurt and because no one understands. I will talk with my Doctor about Cymbalta, but, so much negativity about it scares me. I am 54, I work, so there are days I just can't make it to work. That's what upsets my husband.
Cindy
14 Nov 2009, 10:12
I to am a fibromyalgia sufferer but it amazes me that you people are worried about weight gain. I have been suffering with the fatigue for many years but drs. kept giving me antidepressants. Along with the fatigue I had numbness in my hands in the mornings. The neck pain didn't really bother me thought it was a part of life, being a wife and mother. In March 09, I was finally diagnosed with fibro. Couldn't tolerate Lyrica so I was put on Cymbalta 60mg daily which was alright later I was given Tramadol ER and klonopin. Even with all this the flareups seem worse. I feel like I lost myself. I was never this bad. So this is my 3rd day going cold turkey without those meds just tylenol and let me tell you that the withdrawls are hell. But I am determined to be my old self again. This cymbalta and tramadol are evil things. And try going to the emergency room during a flareup and see how they will treat you like a junkie trying to score pain meds when that's the last thing you want. Right now my only hope is that the steroid and lidocaine injections to my shoulders and hips will help. All i want is my life back not for my sake but for my childrens. Good luck and God bless us all.
Rosemary
08 Nov 2009, 15:17
I have experienced fibro pain for 40 yrs. At least 20 yrs without the proper diagnosis. I am reasonably comfortable taking Ultram, 4 every 6 hrs and Mirapex for restless legs, 1-2 daily. no jumpy legs or pain.
Patricia
08 Nov 2009, 02:14
For years I have worked like a man, carrying heavy item, stayed busy way up in the am, long after all was a sleep. when I finally did stop, my body would ache all over, I just dismissed it as overworking myself and a reason for my pain. till as i got older, now 55 in years and not in body, just couldnt take the pain, cramping, tingleing, burning of my muscles everywhere, that I finally started complaining. My dr put me thru MRI's,blood test,heart scans,tested me for blood clots since i have a family history of, to find i was one fit 55 year old. she referred me to a neurologists, which also did his blood test, this dr tested me for all virnal diseases, which was embarasing,posioning,lupus,leukemia,also a family history,the works to find also a fit 55 year old, he scheduled me for nerve damade test, which he did personally himself, only to find all good. his thoughts was i had fibomylagia, but referred me to a rheumatologist. which after his exam said i had all 18 points of fibomylagia. So now i have the diagnosis, which my insurance company didnt want to give me the meds,why is it, when your in pain everone looks at you like you a drug seeker, before fibo i never even took a aspirin. i have had a baby,gallbladder removal,bi-arractic surgery where they cut you from belly button to your breast bone, and i never once took pain medication home with me. now that i hurt so much, my dr informed me today that the FDA will only approve 90 mg dly on cymbalta. she dont want to give me any pain meds but one daily, well i wake up every morning moving like a 100 year old woman, take my cymbalta and its time released, so it takes a couple hours for me to even be able to move about like i'm death warmed over. then it works where i can tolerate the pain, and i do have a high tolerance, but let me tell you its wearing thin. and the sad thing about it no one believes you. well I'm not ready to lay down yet, and i am not a depressed person, i am the one everyone looks up to. i just wished there was some test to measure fibo, and a med that took it all away, so i can get on with my life, the fibo has made a huge difference between me and my husbands relationship, because i dont feel like doing the things with him that i use to, and he is in his late 60's and gets around better than i do. after reading all the comments i realize i am not alone...and ladies i feel for you. hoping some day there will be a cure, or at least be recognized as not being crazy.
Becky
06 Nov 2009, 22:46
I have taken just about everything for my fibymyalgial. Back in the day before doctors began using the SRI's, the only treated with pain med which we all know does not work. I began treatment with a rheumatologist at a well know University school of medicine in the early 80's. I have taken them all, and most seemed to work for a while, they all had some side affects, weight gain and sweating, the two biggest. However, they are the only medication that has ever helped me.They control the pain and fatigue the best. I've been taking cymbalta now for about two years and have good luck with it. However, having said that,I worry what would happen if I quit. If I even miss a dose, I start having withdrawal now, after just a couple hours. But, I've finally decided that while I can, my quality of life is important and I spent too many years just going through the motions and not living.
Bev
05 Nov 2009, 23:23
Cymbalta has helped but the sweats are horrific and embarrasing and there has been weight gain. I have had fibromyalgia for many years. It started after major surgery and came on like a hurricane. Isn't there something that will help the pain but not cause weight gain and sweats that are unbearable.
Emily
03 Nov 2009, 16:08
I am currently taking Cymbalta for fibromyalgia and, so long as I listen to my body tell me when it is time to stop, I can do pretty much what I want to. I am still in pain and have some fog but not enough to stop what I want to do. As for weight gain, one of the little known side affects is an appetite suppresant. I have actually cut my eating in half and lost weight. I am not saying it will do the same for everyone but this is my experience.
Dorothy Zaragosa
03 Nov 2009, 10:58
I currently am on Enbrel for my RA (I really don't want to claim but it's there) plus Imuran, for the Fibro I take soma,vicoprofen and klonopin. Still many days of pain and fatigue I think what bothers me the most and is very stressful is that there are people close to me (like my husband) who doesn't understand. That can hurt worse than the pain itself.
My Doctor is asking me to try Cymbalta and I to struggle with the weight issue, I have lost some to have it put on again, I don't know about that.
Lorie
25 Oct 2009, 16:46
Trish,

I'm curious as to why you stopped taking the Cymbalta? I understand and am very aware of the issues that usually come with stopping an antidepressant as I have personal experience with it as well. However, I mad a choice to stop taking the antidepressant (Zoloft) due to a side effect I could no longer deal with. Anyway, that was about 12 yrs ago and it was not prescribed for pain as I did not suffer with pain or fibromyalgia until after a car accident in Nov'04. I'm simply agreeing that withdrawals and the possible side effects from them are often not thoroughly discussed at the time of prescribing these kinds of meds to patience, etc. That said, I guess I’m also not just wondering why you chose to stop taking the Cymbalta after 3 yrs of use (most especially if it was benefiting you), but I also wonder if it’s possible you may not have been weaned off the medication properly? I was weaned off of the Zoloft accordingly, that was not an issue, but I still experienced withdrawal symptoms that I would have much rather done without; so I do feel your pain, only my withdrawal symptoms improved over a 3-4 mth period and never gave me trouble again. I’m sorry to hear that yours have persisted for so long.

My second question is a general one to all. Has anyone experienced weight gain after starting Cymbalta treatment for fibromyalgia? That is my BIGGEST fear. I struggled through most of my 20's with a serious weight problem (standing 5’4 in height and fluctuating between 185-220 lbs) but had lost the excess weight over a 2 yr period then maintained a weight of 122-127 lbs throughout most of my 30's (I’m now 39) with exercise and diet. However, in the last 18 mths I've gained 22 lbs due to a 2nd car accident which seems to have made my fibro. symptoms more bothersome than before, most especially my fatigue and the pain I experience in my arms and lower back. I am very upset and frustrated by this weight gain and absolutely will NOT be able to endure that kind of side effect...the extra 20 lbs on my body is already making the pain in my back, hips and legs, worse. Weight gain is not a side effect I’m prepared to deal with and accept.

This now brings me to my last question. For those of you currently taking Cymbalta and benefiting significantly from it, would you say that the pain and fatigue has improved enough that you’re able to begin and maintain a more regular workout regimen? I don’t mean heavy weights and going fitness crazy, but I very much like the thought and hope of being able to start walking longer distances and/or at a faster pace more regularly (w/hope of losing my recent weight gain). If anyone can answer my questions, please let me know.

Sincerely yours,
Lorie
trish
09 Oct 2009, 17:21
Not trying to scare all the fibro sufferers but if or as soon as you can please ask the doc to taper you off NOW. I have the unfortunate experience of the poison they call cymbalta .Still experiencing side effects after being off for over 3 yrs and still have withdrawal effects. It is not normal to have these kind of side effects from a pill.Google cymbalta withdrawals and you will be surprised to know the thousands going through this. ELI LILLY has kept a secret from the docs about the horrible withdrawal & side effects. Insomnia & anxiety,vertigo,nausea bladder problems, deteriorating teeth ,ringing in the ears, tardive dyskinesia, tardive akathesia,BRAIN ZAPS, just too many to name.This information is from someone who has experience and is aware of the lack of knowledge of docs (they know nothing of the dangers of quitting cymbalta)they will say it shouldn't effect you like that.Drug was put out only after an 8 week trial. Very sad. This is not a wonder drug. It shouldn't be too long before the lawsuits start coming in. Again docs know nothing of this, only the unfortunate users.
Even after you quit cymbalta & still having problems 3 yrs later is a huge red flag. If you don't ever want to experience this you must be on for life which means you can kiss sleep away. I only get to sleep 2 hrs a night if I'm lucky so thats about 12 hrs a week. Very dangerous. I'm just trying to help. I was put on cymbalta for fibro & depression for 3yrs. Still suffering & have additional symptoms & problems because of it.
Cymbalta has ruined my life. Depression hurts, CYMBALTA hurts more.
Gail
08 Oct 2009, 13:44
Iam 57. I was diagnosed with Fibromyalgia in January 2007 after 3 months of xrays and labs. I also have a herniated disc, carpel tunnel, osteoarthritis and restless leg. I was given Gabipentin,Celebrex, Lorazapan and Vistiril. I am permanently disabled and receiving medicare. Hospitalized for major depression in April of 2007. That is when I met a Psychiatrist and began using Cymbalta. 2 months ago my husband lost his job and we lost our insurance. I ran out of drugs. I went into a depression and withdrawal (tears & screaming). Now with SCAN, I am back on my meds everything is getting better. I didn't think anything was working but thse drugs dull the pain quite a bit. A Rhematologist said the side effects of Lyraca is worse than this disease.
Marie Hoffman
07 Oct 2009, 09:20
I have RA, FM and herniated discs and severe spinal stenosis among other things...a couple of years ago, the Rheum. put me on cymbalta for the back pain...it truely gave me my life back. I am 58 and work full time plus OT as an RN. It makes the pain tolerable...not gone..but tolerable. I still have flares, but with Mobic, that is helped. I also take Methotrexate.
The only down side to the cymbalta-excessive sweating of my face and head. It is terrible. If it is at all warm or humid..I have sweat dripping off of me. If anyone has any suggestions as to what to do about that, please let me know. It is embarrasing and uncomfortable. I take 30 mg a day...can't imagine if I took a higher dose.
To my fellow RA and FM sufferers...hang in there and keep smiling thru the pain....and never give in or give up...on the days you don't feel like it, get up anyway, take a shower, put on your lipstick and go out somewhere..even if it is to walk in the neighborhood..got to the store or mall and windowshop..just get up and move...and never, never give in to these diseases.
Marian
20 Sep 2009, 20:57
I was diagnosed with fibro ten years ago, and have tried various meds. I've had good results with cymbalt and ultram. For sleep, trazadone works best for me. It acts quickly, and I sleep well for 6-7 hours. I have very little daytime drowsiness with trazadone, unlike other medications I've tried.
Edith
17 Sep 2009, 16:30


I am on my tenth year of a Fibro diagnosis.

Since I began taking Cymbalta, I have noticed a considerable reduction in pain, Fatigue, and fog.

Since I have been on antidepressents for ten years, I was surprised to learn that Cymbalta boosted the neurotransmitters (serotonin et al).

Sleep is still a problem, but that is nothing new.

Any info on sleep would be appreciated.
Lydia
11 Sep 2009, 14:28
I have spendt 2 years with chronic pain, and the doctors thought it was RA. I had been taking NSAIDS,and pain meds all this time to help me with my pain. Finally a few weeks ago my doctor said that my symptoms have gotten worse and seemed to be like fibromyalgia. She started me on samples on Cymbalta, and after 1week, I was a completely different person!!! I feel so good, minimal pain. The pharmacy recently told me that the insurance company did not cover the Cymbalta. I was so upset, I have waited years to find a med that works. Does anyone know what I should do? Is there another med, that would give me the same effect?
Dottie
01 Sep 2009, 18:50
Hi! I am sure glad to find this website. I am a nurse who not only has Fibromyalgia but a back injury at work. I am now on disability but do pick up a few shifts at various places. I also had leg cramps at night. I was taking Klonopin 1mg at bedtime but it didn't help. The doctor increased the dosage to Klonopin 2mg at night and it has stopped the cramps altogether. I also take Seroquel for sleep. It is for psychiatric disorders but it is the best thing that I have ever taken to get a good nights sleep which is important for patients suffering from Fibromyalgia.It is not habit forming.
Maureen
25 Aug 2009, 13:27
I tried Cymbalta several years ago when I was suffering from severe pain. I thought it would be the answer when it took away every bit of my pain, but then I developed the strangest side effect: the palms of my hands and the soles of my feet turned beet red!

I couldn't walk and I couldn't use my hands. Well, of course, I stopped the drug immediately. I was free of pain but wouldn't be able to function in my daily life!
Teresa M. Smith
22 Aug 2009, 02:28
To all Fibromyalgia suffers:
I am a fellow fibromalgia patient and also have PSA arthritis, with Psoriasis diagnosed at age 8 years old. Back then, all dermatologists treatment consisted of coal tar ointment and photosynthesis or sun light treatment. No one knew there would be other problems to tend to when the Psoriasis becomes dormant or in my case went inward and affected my joints. I remember my knees being covered with large white patches, that resembled someone kneeling in "flour". I have painful knees now and also the affects of muscle weakness and severe muscle cramps to legs and lower back during the night. I am a nurse and work 7 on and 7 off, which keeps me on my feet. I know I must continue to walk and be active or I have a severely painful day. I have been taking the Humaria SQ injections every two weeks and give them myself. I also take Ultram ER and occasional arthritis strength Tylenol 1 every 4-6 hrs. and not more than 4/day.I have also been placed on Cymbalta and find it to be very effective in assisting the "break through" pain and depressive side of the disease which is manageable. I also take Skelexia when I havee the muscle spasms. It does not last as long as the narcotics, but are much safer and I function well while working and still having to take the medication. Being a nurse I know only too well how someone can become addicted to pain pills, even for a short time. People be aware that pain medication was originally designed for short term use. Now with the "Chronic Pain" patients. and fibromyalgia sufferrers, they have become first choice. Exercise is also the key to good coordination and muscle strength.A good nutritious diet will continue to provide the protein muscles need to stay healthly.Keep on working you guys,
Very truely yours,
Teresa M. Smith RN/CCM
ann
18 Aug 2009, 13:07
I have been 60 mg. of cymbalta for a year now. I do have reduced pain; but still have fibromyalgia flare ups that are truely painful. I have also developrd terrible sweat attacks which seem to a side effect of cymbalta. Has anyone else had this problem? Does anyone have a suggestion for reducing this embarrassing problem?
Cheryl
04 Aug 2009, 10:18
I took Cymbalta for about three months and didn't notice much difference in how I was feeling. As soon as Savella came out, my doctor put me on it. It is incredible!! I have been on it about 2-3 months now and I have only had 2 bad days the whole time. Fatique was a huge problem for me and it isn't happening now! Pain is almost all gone. I feel like a different person. Yeah Savella!!!
V S
17 Jul 2009, 19:35
Gloria -- is your rheumatoid arthritis better now...?
Gloria M Tate
24 Jun 2009, 02:55
I have only been on Cymbalta for a month, but right after I started it, I felt much better. I am not taking quite as large a dose as the doctor wants me to take, but the results are great, even on the lower dose. I have more ambition than I've had in quite some time. I also take Tramadol for the pain.
Joyce Readus
02 Jun 2009, 18:03
I just started taking Cymbalta on the 14th of may and it hasnt been a month yet,and I wondering should I raise my dosage instead of 30MG to 60MG? because I hurt really really bad and I am sad please respond back and give me some suggestions, Thanks Love Joyce
Karen Turner
17 May 2009, 20:10
I have been on Cymbalta for a few years now for Fibromylagia. Cymbalta has cut down on my pain quite a bit, however not completely. Also, I suffer from fatigue quite a bit still. I have terrible leg cramping and wake up a lot at night. I also have bladder issues lately and wake up to go to the bathroom at least two to three times a night. My doctor thought that adding Lyrica once a day would help with more pain. It did help to ease more pain, however I gained 10 pounds every month that I was on the Lyrica. After gaining 40 pounds of extra weight I couldn't handle the weight gain and took myself off of the Lyrica. It is worth trying but beware of the weight gain! I just read that Cymbalta can cause Restless Legs, which I have terribly at night and sometimes during the day. My doctor put me on Qualaquin and Klonopin for the Restless Legs, but neither seem to help. If anyone knows of some other drug that would help with the Restless Legs that I could take that would be helpful to know about, could you please let me know.
Kellie
06 May 2009, 13:33
I have been taking Cymbalta for a few years now. I did notice a reduction in pain, but I still suffered many days with intense pain and fatigue. As such, my doctor added Ultram ER. The difference was overwhelming! I still have occasional bad days, but much more manageable. I am reluctant to try Lyrica because of the side effects and what if it doesn't work as well as what I am taking now?
Regenia Harvey
05 May 2009, 16:54
I have been taking 120mg cymbalta for some months now and to some degree it helps when my pain is not so bad;however, I'm afraid to try lyrica because of the possibility of weight gain because I'm trying to keep my weight minimal because of the effects it may have on my joints. I can't tell the difference in my cfs but hopefully I will get some relief with that also.
terry
05 May 2009, 11:18
I have been taking cymbalta for 7 months no.Almost immediately I felt a difference in my pain level.The pain is not gone but cut down compared to what it was.I am able to do more and sustain my energy to where I can halfway enjoy my life again.Also taking a nap during the day cuts down the tiredness.
Suzette
23 Apr 2009, 12:31
Thank you for providing such useful information about these new fibro drugs.

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