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Methotrexate Injection

Q: Is there any benefit to receiving methotrexate by injection as opposed to taking it orally? Is it metabolized differently? Are the side effects of methotrexate injection different?

A: Methotrexate is a disease-modifying antirheumatic drug (DMARD) used to slow the disease process and treat the pain and swelling of rheumatoid arthritis. The body's absorption of the drug, and therefore its effectiveness, varies among individual patients when the drug is taken orally. To improve methotrexate's effectiveness, physicians may increase the oral dosages or try intramuscular methotrexate injection. 

Although the injections may help improve the medication's effectiveness, the potential side effects and benefits of methotrexate are virtually the same whether it is given orally or by injection. Liver damage remains the main concern, and is monitored by frequent blood tests. Taking 1 mg of folic acid per day can help reduce other side effects related to methotrexate use, such as mouth sores or gastrointestinal irritation.

David Pisetsky, MD, PhD, Rheumatologist


Philip
29 Jan 2012, 10:20
I have had RA now for three years the 10 methotrexate pills, 2 folic acid pills everyday (6 pills day before & after), plaquenil, 1 daily calcitonin nasal spray and oxycodone daily makes me very nauseated, very bad stomach cramps on top of neck, back, arms, hands, knees, legs and feet pain limits my mobility as I now get around with a walker because of weakness and pain. My dr just started me on injections. I'm hoping it helps me feel better. Cause eight now I'm miserably sick and the constant bowel movement is irritating. Does anyone know if there an alternative for folic acid? I dread each day taking all these meds but need help
pam camilleri
28 Jan 2012, 07:58
hi, my name is pam i am 59yrs and have had RA for 5yrs. i started on meth tabs and sulsafarine and was much improved for short time then went onto injections weekly with no side effects but RA didn not improve so had to go to infliximab monthly infusions. real pain had to be hooked to IV in hospital for 5hrs each time but RA much improved with this,all was great until i got the cancer diagnosis which meant i couldnt have the IV treatment it can inflame cancer cells so we now back on meth injections due to start next week hopefully no side effects had none previously so should be all good just hope i feel as good as i did on IV treatment good luck to all who about to start it.midd
GMJane
10 Jan 2012, 13:41
Have been on MTX injection for I year for dermatomyositis.Dose 20,now 40.Liver function been consistently OK.Am 77 and hoping to 'live well' into late 90's as women in family have.My symptoms have improved or stabilized.Will suggest anyone with autoimmune anything begin research and reading on basic nutrition and alternative treatments.Homeopathy is effective for me. Specifically arnica for muscle and rhus toxidendron for joints. Am also celiac and all efforts to heal intestinal issues have increased my healing.The gut is amajor player in immune system.Digestive enzymes are a start,then look at systemic enzymes which also heal.The time for research is worth it.Go to library to begin.Also consider a naturopath.Told my rheumatologist and she was willing to work with this as should most Doc's inspite of their prejudice against alternative treatments.Your posts have helped me so hope this contributes to your living better.
Mandy
08 Jan 2012, 22:22
Hi there,
I was diagnosed with RA at the age of 3 and am now 25. I started taking Meth at about age 7 and still take it. 2 years ago I contracted mono and for some reason it put my RA into remission for about a year, but then came back even worse. Doctor suggested a larger dose of 8 pills and I asked about injections after that. I have been on the injection for about 5 weeks and have been having dizzy spells and episodes where I feel faint and sweaty. I see here that other have had that effect too. Does anyone know why this happens, if it's just the injection form or the dose maybe? It also seems to make me more liekely to feel faint when working out. Thanks for any suggestions!

Mandy
Kelley
20 Dec 2011, 08:36
I was nauseated too on oral Methotrexate. I am now on injections and starting Humira injections as well. Nausea went away when I switched from oral to injections. I hope it works well for you too! You deserve some pain free years.
Kim owens
14 Dec 2011, 14:39
I have had RA since being 7 years old, I have been prescribed so many medications neproxin at first which irrupted my stomach, prediscilone, embrl entancept injections, then methatrexate which worked well for many years but now at 27 I feel like I have stepped back in time I am a very sore 7 year old and very tired, which is no good now I have a beautiful active two year old. After a visit to my consultant and several steroid injections, they are thinking of putting me on methatrexate injections, I am a little scared as I don't want the side affects taking over my life. The tablets make me sick the day I take them and the day after, what's the injections like??? Advice very much appreciated I just want to be a fit and healthy mummy and not let my little girl down
letty
13 Dec 2011, 15:23
I inject methotrexate once a week on a friday and for three days after that I feel sick as a dog and have dizzy spells. Maybe I have struck unlucky? I feel ill and tired all the time, which is not great because I am training to work with children. Can someone please give me some advice please?
Lanita Justus
02 Dec 2011, 21:01
Hi,
I was diagnosed with systemic lupus and RA 14 years ago. I am 45 years old now and I feel like I am 85. Different meds throughout the years including steriods, plaquinine, pain meds, and 6 months ago I started 80 units of methotrexate injections. The first 6 weeks were terrible...nausea, chills, stomach pains, ect. Then those side effects left. However, I am still having alot of swelling in all of my joints so my doctor wants me to consider Orencea along with the methotrexate. Unfortunately, my immune system will decrease and since I am a teacher, I am always in contact with different viruses, colds, and flu. So I don't think that will be a good choice for me. I can not take the folic acid because it makes me very sick. I am always tired or weak. Is there anything that can give me a boost of energy? I can deal with the pain more than I can deal with having no energy. Let me know what there is please.
Alice
29 Nov 2011, 14:55
I have now had RA for 5 years (I'm 29). I was taking 15mg methotrexate tablets for about a year with no problems, but then started feeling really sick the next day - I hated taking them and even thinking about them made me feel awful. I was then told I was is remission two years ago, but now having a large flare up. I've tried taking methotrexate tablets again but even 5mg has an effect. My doctor has now advised I try the injections instead as has reduced side effects, also will be on sulphursalizide as RA not responding as they would like.

I try to solider on and not complain but it's really helpful to hear you all have similar experiences. I have never met anyone with RA of the same age as me, people thinks it's something you get in older age. It's been really helpful ready this page.
lynn muir
27 Nov 2011, 10:44
i have been on the tabs for 6wks,then injections,severe bleeding from the anus,taken away by ambulance,injections taken off me,be carefull.
julia
08 Nov 2011, 08:29
im 20 years old and recently diagnosed with RA. i have had the pain for years now especially in my hands since i was about 11. i started Methotrexate injections just 3 weeks ago and have been experiencing random moments of sweating and being drowsy. i am also on mobic and tramadol. i have also been experiencing real bad flair-ups in my hands to where i cant do much. i never had this problem before i started the methotrexate and i was wondering if the injection had something to do with it. it is so difficult especially when trying to do my work for my college courses.
reetha
06 Nov 2011, 01:01
I am having RA,and on tab methotrexate 15mg wkly
How long i have to take? What are the side effects ?
Crystal
05 Nov 2011, 19:00
Was diagnosed with RA about four months ago. First took 6-8 pills and always had sore stomach and diarrhea on or after pill day so they switched me to injections. I like injections instead of so many pills. It has been two weeks now and I feel like crap. My stomach is always sore and I feel so tired. I suffer from acid reflux too and that has been acting up so I go from nausea/diarrhea stomach cramps to bad heartburn. I feel like stopping all medications. I also take naproxen occasionally or indomythacin. Is it possible for side effects to get worse with injections or am I just having a couple of bad weeks?? Somebody's opinion would be great. I am so sick of either being so sore from my joints or sick to my stomach?? I don't know what is worse right now?
T.
17 Oct 2011, 20:25
Hi, I was diagnosed with RA 2 years ago, although I believe I've actually had the disease at least 4 years. I was started on Mobic once a day prior to the diagnosis and took this for about a year, then with the diagnosis of RA, Plaquenil was added, which I couldn't tolerate at all. I was switched to Methotrexate pills starting at a low dose and worked up to 20 mg a week over several months. I had so-so results, nothing spectacular after one year. I discussed with my rheumatologist that I also have irritable bowel syndrome, that maybe I was not absorbing the pill form, so I was switched to the same dose in injectable form 2 months ago and have had noticable improvement with this. I have had much less swelling and pain since starting the injections and I'm tolerating it well. For those of you dreading starting injections, it's quick, easy and nearly painless- it's very tolerable. I inject on the side of my thigh so if you're afraid to do the abdomen, try the thigh. I also divide the .8 ml. dose in half and do a .4ml injection twice a week. I inject on Sunday at the beginning of the week, then again on Wed or Thurs to get me through the rest of the work week. My job is very physically demanding and a divided dose seems to give me the boost I need by mid week. I think I'm finally on the drug combination that's going to work for me. I am still on Mobic, and take 1 mg of folic acid daily and have blood tests every 3 months. Good luck to those of you starting injections, I hope you have as good a result as I have had.
Brian
01 Oct 2011, 17:50
Injectable MTX is much more effective for me (scleritis, ankylosing spondylitis). Recently 2 mfrs recalled the no-preservative Multi-dose vials, and 2 other mfrs are shut down. So yes there is a supply chain problem. Walgreens expects new product in stores by Nov 2011. CVS knows nothing about why or when there will be injectable MTX. Tablets are available.
Ron
21 Sep 2011, 15:32
Answer to Pat, my methotrexate is also on backorder. Don't know what to do.
Kharmin
19 Sep 2011, 21:39
I have been diagnosed with RA for 7 years now. I had the symptoms for 5 year prior to being diagnosed but did not go "Full Blown RA" until I stopped nursing my second son. During pregnancy and nursing it was almost like I was new again but it came back with a vengence, like a thief in the night, I call it.
I crawled into the Doc's office and begged for help. He said are you done having children and I said if it means you will give me help , YES! If I cannot take the cap off of a baby bottle or run with my 2 year old or risk passing it on to someone else! I'm done , give me help.
7 years of methotrexate (15mg week), 5 years of plaquenil, folic acid and predinsone every now and again. I work out 5 days a week, mountain bike ride when I can, play with my very active boys and love life !
Yes I get down but I have to WARRIOR UP!I am glad to hear your stories for I feel like no one can understand the pain but people whom have experienced it. My darkest days were soon after my second son but get help and keep your head up. You have to keep moving .
I tried the injections after my tummy aches hit 12 hrs just like clockwork from my methotrexate pills and I called them meth headaches. The injections I did not do a good job on and had too many flare ups and yes they seemed to be out a good bit of the liquid methotrexate, so I went back to oral and dropped hydroxychlorquine in year 5.
Warrior Up and yes much prayer to all of you RA sufferers!
Patty brandao
18 Sep 2011, 19:00
Hi, I've been on methotraxate and plaqunil for 3 years. Recently have lost alot of weight and depression. I'm thinking it has something to do with not enough folic acid. Anyone have experience with this?
Tricia
16 Sep 2011, 22:47
Hello, I am on the injectable Methotrexate once a week and have been on it for about 3 months now for a servere case of Dermatomyositis, which is an autoimmune disease. This disease attacks my muscles and skin. The shot has helped me a lot but I am still not well. My body is very sensitive so of course, I had a lot of the side effects. My doctor has me on 5mg of Folic Acid a day which helped some but every time they upped my dosage it got worse. I am now taking 5mg of Folicinic Acid the day after the shot along with the daily Folic Acid. I also take Plaquinil and a low dose of Predisone 2.5mg because I cannot handle steroids. I have had the disease since September of 2010 and I am hoping to feel some what better by this Christmas 2011. Anyway I did want to let Pat know I just went to the pharmacy and yes, my Methotrexate is on backorder. They could not give me a date of when it will be in. They issued me the pills instead so I am hoping my progress does not change nor will I get added side effects. I am located in Indiana.
Pat
14 Sep 2011, 15:14
I am having trouble getting methotrexate injectable refilled, says it's on back order. Is anyone else in the country having the same problem?
Steve
09 Sep 2011, 10:17
Have been on injection Methotrexate for the last 6 months and find it no problem. Was on pills for 6 months along with a raft of other meds including prednisone. SLOWLY decreased the prednisone and finally am off of it. With prednisone I would bleed even when I just rubbed against a door. I still find bruising very common but no bleeding. Decreased methotrexate to .5 ml per week from 1 ml but now taking Laflunomide 20 mg pill every day. This started when I came off of prednisone (THANKFULLY). Still need exercise but only once in a while do I feel pain in my hands. Good luck to everyone with rheumatoid arthritis.
Professor
26 Aug 2011, 01:47
56yo with RA for 2 years, recently switched from oral to injected MTX with only mild side-effects (passing flu-like symptoms), not even every week. Shots are "no sweat." Best: MTX seems to work for me!
Cindy H
08 Jul 2011, 14:28
Was diagnosed w/a touch of RA, Polyarthritis, Osteoarthritis, and Degenerative Disk Disease several years ago or so. Was only having minor arthritis issues after retiring from the Army 10 yrs ago til a trip to see my daughter about 5 yrs ago. I've been in pain ever since. I'm getting ready to start taking Methotrexate by injections starting this weekend. Don't particularly like needles, but, will give it a try. I've been taking 15mg Methotrexate, Plaquenil, Sulfasalazine, Folic Acid, Calcium/Vit D, and Prednisone. Every time I get off the Prednisone I boomerang back into swelling and pain and end up right back on it. Am hoping for good results w/the injections as I've not had any problems w/the above mentioned drugs/vitamins. The other shots/IV's aren't an option as there's cancer in my family and I'm just not that gutsy. There have been a few other drugs tried that I'm unable to take due to being too sensitive for the side effects. I'm okay w/not running, but, would love to be able to walk for more than a half hour w/o pain. Fingers crossed and prayers said! Good luck to you all!
andrew quinn
25 Jun 2011, 12:23
i just been diganose in the last month with .R.A. and just been put on methotrexate this the 5ifth week so far so good, no side effect, but had bit of r.a. in shoulder befoe i was put on it, and seem to be abit more painful, now in thes last few week since starting takeing the tablet but kness and legs are a lot better i was wonder wondering if people had simalr or same probamly as me i would like to here your view
to all r.a hope your conditoin inprove,
andy
Texas Fletcher
23 Jun 2011, 00:14
I'm 33. It's been 7 years of RA for me. After two years of farting around with the small stuff, finally settled on Remicade, methotrexate 1cc injectable, and 5mg prednisone every day. (Add to that Actonel to counteract the prednisone.)

Hallelujah. I can do a freaking cartwheel.

I hate the injection. My mouth produces an awful taste when I even think about it. It's is so strange. So, Jane, I totally feel your pain. But we do it, because it's working.

We do it, because we want to run in the park with our kids (I have three-- 5, 7, 9). We do it, because we've tried fish oil and gluten free and candida detox and every other natural thing out there, and the reality is... If there was ever a time to get RA, it's now. Because they're getting better at fighting it, and were reaping the benefits.

Stay strong. Eat right. Exercise. And don't miss an injection or a lab check. Ever. And one more thing...

Pray.
Jane
10 Jun 2011, 02:00
I have been on Methotrexate 1ml-25mg/wk via injection for nearly 2 years now, after being diagnosed with Psoriatic Arthritis. It has certainly worked wonders for me, however I am finding instead of being more confident giving myself the weekly injections, I am more nervous and at the point of hating it so much I am thinking of changing to the tablets. The thought of injecting myself in the stomach actually makes me feel sick, rather than the injection itself! I am seeing my Rheumatologist again in August and will ask him if he thinks it's ok, as it would be such a relief to never have to inject again. One of my concerns though, is that I read someone above say that the liver absorbs the tablets far more than the injections do, and I enjoy the odd glass of wine allowable. Anyone in the same boat?
Rick
30 May 2011, 12:30
i am a Gulf War vet and I have RA, chronic pain syn, and an autoimmune disease, I was on the methpill which like the rest of you made you all very sick, I was switched to the injectable meth along with the hydroxychloroquine sulphate to help with the RA and the autoimmune disease (the injectable has a chemo in it if you didn't know). I have been taking it for 8 weeks now and the only real side affect has been fatigue. Won't know the affects on the autoimmune disease yet until some test are done. Widh you all well in your pain management and treatments. Hope this helps
james
16 May 2011, 09:50
Hi,
I am a 33 yr old gentlemen who was diasgnosed with a spondylo arthropathy in March 2010

The dr thought it may be sporiatic arthritis, but is now not too sure

My dad had ankylosing spondylitis and sadly passed away in Jan 2011

Dad had been taking long term indomethacin which ultimately we fear led to a thining of his bowell and he suffered faecal peritonitis

have been taking methotrexate 25mg tabs weekly for 4 months and am feeling the benefits

considering the injection instead , but am not a fan of needles :-(

My question is, is there any clinical benefit to the injection?

I am tolerating the tabs, occassional upset tummy but nothing major so retisent to change unless there is a significant benefit

I also take prednisolone 10 - 15mg a day, etoricoxib 90mg , folic acid and a ppi

my dr doesn't advise that diet is that important, but i feel orange juice, grapefruit and steak is best avoided?

I also want to do a bit of travelling, so figure that a tablet form would be easier than injections

Not being able to drink on methotrexate is a bit of a bummer as this was a big part of my social scene - but if it means i can carry on and live a relatively active life, then i will stay on it and not drink

not sure if other meds for our Arthritis stop you from being able to drink too?

My dad never let the the condition 'have him'
he always would say that he had the condition

I know how important mind set is with this condition - we all want a cure I am sure

Any thoughts / advice jamesculley@yahoo.co.uk
Maureen
30 Mar 2011, 04:11
Hi. Every one got my first shot of mex on monday so far no side effects Would advise any one 2 go on injection as when i was on oral was so sick all the time ,
Having second shot next monday so hopefully i will not get the side effects back,
Could any one tell me how long do the shot stay in your system.or will it build up in your body every week?????
Good Luck to all with their R/A and please god we will get through this pain and feel a bit better,
Maureen Ryan
25 Mar 2011, 08:28
Hi,
I am just about 2 start met injections today after reading all the comments i feel better about it. I could not tolerate the tablets at all so i am hoping the injections will work for me.
Hope every one on here the best of luck.
Will pray for every one that has r/a and in pain.
I have very bad pain so i am hopeing the injections help me .
Headacheslayer
02 Mar 2011, 04:30
I have psoriatic arthritis and ankylosing spondylitis. Just got DX'd back in October 2010 but I've probably had it for years and kept getting the brush off from rheumatologists (I also have fibro among other things). But thankfully I found a wonderful doc who believed in me and started me on methotrexate/folic acid.

I'm up to 20mg (8 pills) and she just switched me to the injected form because my nausea has been *horrible*. I have to take zofran every day, sometimes it's so bad I cry--I know, sounds crazy but it's 100 times worse than the "morning sickness" I had with my kids. Plus it makes my chronic headaches/migraines worse--so those two side effects make me miserable.

I really hope the IM form works because I know the MTX is working--my skin has cleared up and while I still have pain, it's better. I still can't walk or stand for more than 5-10 mins at a time (sad, I'm only going to be 41 this month) but the constant pain is better. I don't wake up in horrible pain anymore.

I figure I've had this for probably 8-10 years. I kept going until I found a doc who would listen. Thank god for my regular doc who trusted me and referred me. I already have hip/back damage. Scary to think if I had kept going without treatment!

Take care everyone.
erica
06 Feb 2011, 04:12
I just turned 20, and I was recently diagnosed with a blood clotting disorder. With this, I have to give myself shots to prevent blood clots. Someone asked for a way to make it easier to administer... think, women go through worse pain daily by popping pimples or getting eyebrows waxed.
debra
20 Jan 2011, 14:00
iam 53years old and have suffered with RA since i was 17yrs old and have tried many many drugs. i have been taking methotrexate pills for the last 10years. i have been lucky, no side effects and they suit me well. to me it is the wonder drug that has allowed me to live a full productive life. to anyone out there just starting out with them, give them a chance to settle down, usually about six weeks, it will be well worth the wait. never having the injection i dont know if its better but the pills are convienent to take instead of sticking myself with a needle.
to the guy who's meds are not covering him for the week, go back to the consultant and get assistance , try a higher dose for a while and then gradually drop back down. my experience is that this drug needs regular review and i see my consultant ever three months and have done for the last ten years. we tend to suffer in silence, hiding our pain, i have for 26yrs, its good to be able to speak to others that share this disease.
jim
04 Jan 2011, 09:56
I have been taking methotrexate forever. Now I take six weekly ( the number really doesn't matter) and every time, my joints ache for 2 days. Does anyone else have this problem?
whitney
18 Nov 2010, 14:31
i am a 24 yrs old and was diag. with RA right after having my 3 mo old son. i take methotrexate (6pills) once a week. it is very difficult sometimes taking care of my son. i have only taken the dose twice. so i havent seen a change yet. i have found that prednisone also helps with my swelling. we have to hang in there tho! God has brought us to it.... God will also see us through it! I pray for each of you guys!!!
ron jay
12 Nov 2010, 23:31
i have a good friend that has rheumatoid arthritis and she has started taking shots in her stomack to help with the pain that come's with this type of arthritis. i'm trying to find any information on any way to make these shots easier on her to give herself.
Cara
04 Nov 2010, 09:08
Hi all...

Recently been told I have to take Methotrexate - 15mg per week. Is there anything I need to watch out for specifically and how sick can it make me?
Thank you
Melissa Sneddon
19 Oct 2010, 13:48
Hi
I was diagnosed with arthritis at the age of nine. i was on all sorts of medication that just made me have no energy. when i was put on methotrexate first orally it made me so ill i had some really bad side affects then when i was 12 i got put on the injection. It really worked for me. i had more energy and could walk without having to have someone with me. i am now seventeen and am on 25mg a week. it really does work it changed my life.

best of luck

xx
Cheri
18 Oct 2010, 17:33
I have had RA for ten years and feel blessed that I have been spared some of the heartbreaking symptoms that others have reported. I take methotrexate 7.5 mg per week and do well with this, however the hospital I work for wants me to get an MMR vaccine and I am very concerned abt. this.....can this immunization make my symptoms worse??? My titers are good except for the mumps titer, which is equivocal at .45. Thankyou for a response.
Barb
27 Sep 2010, 12:38
Hi my name is Barb and I'm 59yrs. Three years ago I suffered a pulmonary embloism (blot clot in the lung) at the same time diagnosed with Lupus,RA and osteoarthris. It was all such a shock for me and my family. Also need a knee replacement and walk with a cane. Last tweek I started on the Meth injections, my husband injects me. Other than nausea, not too bad. Can't wait to get some results. I take coumidin (blood thinners) for life, plaqnil daily, blood pressure meds and zolof. I went from a slim healthy energetic mother and grandmother to an overweight bundle of pain. Each day I pray to God for help to get me through it. For all those suffering as I am remember God will listen and answer your prayers.
Mohamed
22 Sep 2010, 19:05
Hi all,
First time i can relate to a group of people -strangers that somehow become close- because of a disease for which a cure is not really available. I've been gradually on Naproxin then hydoroxychloroquine then methotrexate at the high dose of 8 pills a week, plus folic acid. Many side effects that even my wife doesn't know about, so we sort of live this condition alone. I'm switching to the methotrexate injetion upon my doctor's recommendation with a view to get on DMRAD drugs in 3 month-time... Hang in there guys and don't stay still; enrol in a gym or take yoga classes but get on the move. Inactivity just affects your morale.

Take care!
Esmeralda Barrera
16 Sep 2010, 21:29
Hi I have had Rheumatoid Arthritis and this is going to be my first time using the methotrexate inject well am not scare to use it cause I have faith in GOD that everything is going to be OKAY and that this will help me for my own good and I will pray for everyone
Kathy
11 Sep 2010, 05:35
I am 53 years old and I have RA. I was taking methotrexate pills for 4 years and have switched to the injection for the past 7 months with much better results. I also take 2 Hydroxychloroquine tablets and 1 folic acid pill each day. I do experience more nausea lately but I think its due to long time use of the Hydroxychloroquine sulphur tablets. I find changing weather causes my joints to start aching. Swimming allows me to stretch and work joints pain free. Find a fitness center with a pool if you don't have one, it will be worth it in the long run. I pray that through your pain you can still see the light at the end of the day. It is so unfortunate that many face this disease alone. It WILL take time and effort to educate our loved ones about RA -and it's limitations. So until then we will have to make "choice changes" for ourselves, and it's all good. Good luck to you.
Keith
28 Aug 2010, 05:37
Hi
I was diagnosed 2 years ago with Carpal tunnel syndrome. they wanted to operate but I refused as chances of recovery were too slim. Then they did more extensive blood test which found the RA spike. By then i was bed ridden and in agony. I was injected in every joint with steriod which was like a miracle cure for a while. I now take Sulfasalazeine and Methotrexate by injection. Life is miserable for three days following the injection and just as I feel OK its time to have another dose!.
Im thinking of going back to tablet form MTX as the sickness has remained constant.
Is there no alternative to this foul stuff?
Deborah
06 Aug 2010, 00:31
I'm not new to the pain but was just diag a few days ago. I was put on prednisone for the next 20 days and will start the injections shortly after. Not worried about giving myself a shot but rather will i get pain relief. I'm 47 yrs old with 5 kids still home and cant move most days...just praying this works! I will pray for you all!
gill wilson
03 Aug 2010, 12:51
I have been injecting Methotrexate for the past 4 months after 10yrs taking the dreaded yellow pill form ...I cant tell you the difference to the quality of my life, ok I still get tired, headache, but the heaving stomach and dread of having to take them has disappeared..push for the injection form.
Laura B
26 Jul 2010, 00:26
Bless you all. I feel for you because I understand your pain. I try to look at the positive side of being sick and having RA. It has taught me how to have love and compassion toward others.
I was diagnosed with RA twenty one years ago and I have been through a lot. I was 29 when it happened. I was bed riden when I got it.
Sometimes, I feel like a burden to my family. My children and my husband are my reason to keep fighting.
It is very important to have a close friend or family member to be there for you.
My family has been tremendously supportive and that mades me want to keep going.
I have been in ten different kinds of treatments and they didn't help me much, so my doctor gave up on me. So, I begged her not to and she put me on Arava and it was a great blessing. I didn't get any side effects. After ten years of taking Arava, it stop working and they put me on Embrel; it almost killed me, so they put me on methotrexate and it gave me horrible headaches and fatigue. I felt spaced out and exhausted and had nausea. The folic acid improved my nausea. After 5 months, my doctor switched me to Methotrexate shots which gave me stomachache, nausea, and sometimes I feel weak and it's like I have an on and off switch; I change from one minute to the next. The headaches are gone after stopping the pill. Sometimes I feel very weak and like I am going to faint and I get very dizzy and I cold sweat.
It is so comforting for me to read your comments because I know I am not alone, I know I am not hypocondriac, these side effects are real.
I keep busy and positive but sometimes I give in to this horrible disease but I am grateful that I can see, talk and walk and I know there are people worse off.
It is really hard to live with this but I want to tell you all to keep your faith going and never give up. The most important thing in life is not how many time we fall down but how many times we get up and keep going.
I will keep you in my prayers. Best wishes!
Lynn D
19 Jul 2010, 10:46
I have had both my hips replaced (2009 and 2010) I had stage 1 lung cancer, remove the upper right lobe in(2009) also have atrilbribulation of the heart and take 6 mg per day of coumadin and also take lanoxin 0.125 mg per day. Now my doctor (specialist) thinks I have RA because my fingers are getting crooked and I am in pain. The RA flared up because it was a shock to my system due to these operations, My RA doctor wants to try 2 tablets of 2.5 mg of apo-methotrexate a week, followed by 2 tablets per week of 2.5 mg of apo-folic. I am on so much meds already, is the doctor just guessing. I am presently taking plaquenil and Pennsaid for the RA.I also take oxycontin for pain and blood pressure (240 mg) meds. How much can the body take and what effects does taking Metho and apo-folic and do they interact with the other drugs I am taking. You tell the specialists (doctors) what drugs you are taking and maybe they don't listen and somehow some drugs don't interact. My GP has told me not to take the Metho and Apo Folic drugs. I am so confused. Is there anyone or a doctor that could advise me of what to do. All your suggestions will be taken into account. Thank you for listening. I am 71 year old female.
brenda
02 Jul 2010, 21:35
Hello, my name is Brenda im 25 years old i was diagnosed with JRA 2004, bout never wanted to take medication didnt want to admit the fact i had RA but every year is being afecting different parts of my body my knees,shoulders,elbows,wrist,fingers, neck,back and now my feet.Particly all my joints i taken all the pain many nights i woken up from the pain,cried to many times i get depressed every time the weather changes and im in pain, i start thinking of sad thing as well as my RA and think about how i will look when my fingers start to deform so now i will start taking 25mg methotrexate once a week plus the folicacid if you have any advise plz email me at www.pinkhotrock@yahoo.com
Heather
22 Jun 2010, 03:32
I have been taking 10mg methotrexate a week for the last 12 weeks. i take it orally on a monday after tea and i take 5mg folic acid on a friday. After about 6 weeks i really felt the benefit after about 12 months of struggling to walk , bend, and get out of bed. However i find the side effects awful. sore and tender arms and breasts, Dizzy, tired,diarrhea and generally feeling unwell and not myself at all. I have the occasional day or 1/2 day when i feel ok. Does this get any better?
Eva
07 Jun 2010, 15:28
I'm 61 and I was using Methotrexate tabs with Folic Acid / Enbral injections for about 4 yrs. and noticed that my hair was falling out,not a little but alot. Very thinning on top,from a thick head of hair to almost nothing.I talked to my Ra Doctor and I stoped using Methotrexate and my hair started coming back.This is a side effict I can do without.Still not full like I had but I can live with it.Some people may not loose there hair. So now I just use Enbral once a week and melaxacam.I'm not telling anyone not to use Methotrexate , it was ok but I still had pain and felt miserable and head achs for 2 days. Talk to your own Doctor listen to what they have to say.
michelle polit
19 May 2010, 20:19
I am on methoxtexate and have horrible side affects like flu like symptoms chills,fever,aches,sweating . Does anyone else have these or am I all alone? help...
Nicole Muller
10 May 2010, 19:04
Injectible seems to cause a bit less tummy upset, especially if you have IBS or are prone to heartburn or the runs. It also seems to help to split the dose, as other's here mentioned, injecting half before bed one night, and the other half the next. Just make sure and take the whole dose within the 24 hour window. Folic acid, up to 1 MG, should be taken daily (somebody asked).
Becky
20 Apr 2010, 06:34
Hello all,

I have been diagnosed with Rheumatoid Arthritus and Lupus (otherwise know as Rupus) for 2 years now. I started taking 2x Plaquenil per day along with Methotrexate on a Sunday (and also folic acid to counteract any side effects) I must say the folic acid did seem to work, especially if I have suffered with mouth ulcers (if I start to feel like I am getting one, then I take my folic acid and it doesn't seem to be a 'fiery' as previous ones). It has been a constant struggle to come to terms with me being sore, other people not understanding as it's not a disease that can be seen, but the worst thing I have had to contend with is my fatigue from my Lupus. Being quite a bubbly kinda girl, and always on the move, it has hit me hard. I have gone up to 10 tabs of metho per week and have recently been told that it is not being absorbed properly into my body so I will have to go onto injections. It's quite daunting, but reading these about it have answered some questions and given me some more to ponder.

Keep your chin up with it all guys, we are here to be sounding boards for fellow RA and Lupus fellows (I wont say sufferers as I don't ever think that I suffer from it, I'm not dying from it!!!) I refuse to let it run my life, I am in control of my body not my Rupus!!! Be strong guys xx
anika
17 Apr 2010, 12:22
hi

i am 16 years old and on methrexate injections but i have put on weight and i cant seem to shift it are there any suggestions let me know on x-anika-x@live.co.uk

plzzzzzzz help me
Myrna
09 Apr 2010, 21:02
For all those who need to take Methotrexate for the rest of their lives like me...the shots are no big deal once you get used to doing it yourself. Meth has made me feel much better and reduced inflammation dramatically. i take plaquenil and folic acid once a day. you should take these pills with food. No stomach problems if you do. We are lucky to live in a time when we have medicines which really help these autoimmune conditions.
tracey atcheson
22 Mar 2010, 07:46
I have Psoriatic arthropathy and i currently take 15mg methotrexate plus naproxen,tramadol,ondanestron,lansoprazole,folic acid and senna. I have been experiencing a lot of flair ups over the last 2 years and ended up on morphine to control the pain, i have spoken to my consultant about these episodes, and she has spoken to me about injected methotrexate, do you think it works better than the oral medication.
Ramona
03 Mar 2010, 07:20
Hi, when i take oral Methotrexate, I got Horrible headaches almost migraine like, never went to injection, does anyone who went from Pill form to injection,and had bad headaches, will the injection be better?
Pincky Mount
19 Feb 2010, 11:09
Hi!! I'm one of those people that has tried everything. I have been living with RA for 18 years. At this time I am doing injections once a week for the last 2 months. Started with .60; then .80; now 1.0. Also on folic acid and pred. When I was on Humira it really worked. But now that I'm on medicare I can't afford my good drugs. My doctor is talking about orencia. That's a monthly infusion. He said my ins would most likly pay for that. But I have to say the injections have worked better than the pills. Forgot to tell ya'll I am a cancer surviver. One year out. When I was on chemo my RA never was a problem. Funny!!! But I know I will get better. I will not give up.
mandy
17 Feb 2010, 18:40
hi my 6year old son has JIA and has been taking meth for almost two years now, in the beginning he was on the oral dose but would have continues flare ups resulting in into joint injections every 3 to 5 months, he is now on a higher dose and injection form which as worked wounders for him, the only down side is his tummy cramps and he seems to have diarrhea all the time.
Kerry
12 Feb 2010, 04:46
Hi Everyone, I am 29 and was diagnosed with serio negative arthritus when I was 15. I have it in my neck, elbow, both knees and hips, ankles and my shoulders are starting to ache. I have been on methotrexate for 5yrs and have been on 25mg of the injection form for about 10 months, the benefits have been amazing, however I am wanting to start a family and am really scared of coming off the medication. I have read I have to come off for 3-6 months before we can start trying, this seems such a long time and I am petrified of the pain I will be in, but am desperate to have a baby and fear the longer I leave it the worse it will be, does anyone have any advice for how to make this less painful?!? Thank you in advance.
Shadia
28 Jan 2010, 16:36
I Have Neurosarcoid and have tried several of the chemo drugs and so far the Methetrexate is helped the most.
I was on the pill form for 3 months and than it stoped working. so my dr just gave me the injectable. this week will be the first shot and i am hoping it helps much more than the pills. I did lose all of my hair with the pill form but hoping with this my hair loss will be less.
Good luck to you all
Deborah R
17 Jan 2010, 10:57
Thank you all for your statements on RA and MTX, I was switched from the pill to the injections. I don't like needles. I panic. I appreciate the insight on using the thin needles. Its so great to be able to communicate with people that truly know what you are going through. I know its on me for not asking questions about my medications. After reading your comments, I will! Folic acid. I was given it anf had no idea as to what it was. I was and still do depend on my daughter for reseaching my medicatios-and its my neglect for not intaking the things she explains to me. I will do better, I love you all. Its so heart-warming to read your articles and obtain info. I stay home because there have been many times-it seems like an attack on my joints. The pain is unexplainable and I be so embarrassed. Some don't understand/ you do. Thanks so much with lots of LOVE.

DHS-Deborah
carol scherrer
14 Jan 2010, 06:56
my question is that i am taking the methotrexate 25mg in injections per week, I take 1mg of folic acid each day and also on prednisone daily, the thing I am concerned on is my doctor doesn't do the blood test every month, I thought this was one of the main things to have done monthly while on this medication. I started the shots this week and she gave me 2 refills of it and then when I need to refill, then she wants to see me, that will be over 2 months on the shots, is this right?
thanks
carolc
megan swink
03 Jan 2010, 21:52
i have been on the methotrexate shot for about 1 and a half now and im using it to improve my eyesight which hasnt worked very well... im 16 years old and want to loose weight that was caused by the methotrexate, and want to take diet pills but dont know if its safe... if anyone knows the answer to my question please contact me at megan_lovesyou1993@hotmail.com please and thankyou...

Megan Swink.
sam
03 Dec 2009, 16:28
Hi,my nearly four year old son has been on metho trexate injections for 18 months now.He has JRA in 5 joints and since being on methotrexate his condition has greatley improved.He suffered with the sickness for 1st few weeks but it setteled down.He only takes folic acid once a week but this seems to work for him.To any one worried about having injections it really isn't that bad,i injected heperin through both my pregnancys and it is easy and if a four year old can handle it im sure most adults can.One last thing,please make sure that if you have any immunisations to really keep checking there not live(because of immuno suppression) as i asked twice at the doctors and they still injected my little boy with mmr!thanx.
Gina
02 Dec 2009, 14:38
I have been on the MTX for about 6 month now for the treatment of Lupus. I could not handle the pills and went to the shot. The once a week shot has been a lot better. I have had high inflammation in my blood and can't seem to get it under control. Two weeks ago we went up on the dosage because my inflammation went up instead of down. Is there something else to try?
Steven
26 Nov 2009, 04:10
When on Methotrexate you need to be aware of being tired - anemia can be a side-effect -- even for men ! Speak with your doctor if you are overly tired.

The injections are very easy in the thigh - if you feel the needle go in - it is probably dull ;-] - use an ultra-fine needle and you will be fine.

The issue I had is with the 2ml vials of Methotrexate - it is very difficult to draw the remaining 1ml from the vial - and the vials are so small - with hand issues comes more difficulty - try to get the larger vials from your doc.
Alan
24 Nov 2009, 21:58
Hi, I'm new to this site and now I know that I am not going mad, I've experianced most of the side effects myself. I have been taking 8 Meth tabs a week on a Saturady night for the last year and the the stomach pains the next day are hell and I bleed when I poo. I have be told to go on injections next month and I hate needles. I take folic acid 6 days a week but they don't seem to help. Will I still get the rashes and fatigue with injections? I know the meth helps as I am a bass player and before it, I could not play for 2 year, now I play for 15 minutes a day, not great but better than some.
Connie
18 Nov 2009, 08:16
I am 68 years young and was diagnosed 7 years ago. I started with the Meth pills as I didn't think I could give myself a shot in the stomach but my wonderful Dr. encouraged me to try and I did and really there is nothing to it. The thought is worse than actually doing it. I have much better results with the injections. I take a couple of milligrams of folic acid a day to keep hair from thinning. I am so happy to be on metho as without it I would not be walking, I am sure. I feel great and no complaints. Good luck to all of you with this disease. I don't have to look very far to find myself thinking "there but for the Grace of God go I". One has to be thankful for good Docs and a good attitude. lol
Karen in Iowa
13 Nov 2009, 15:20
I have pretty severe mixed autoimmune diseases including RA and have been taking methotrexate injections 18 mg for about 10 years now. It has helped tremendously and is relatively pain free. I still am gradually getting more and more affected with RA but feel I truely would not be walking or doing many of the things I do if I weren't on MTX. I take about 800-1000 mg of folic acid 6 days of the week to keep side effects under control and really notice mouth sores and abdominal discomfort when I skip a dose. The real benefit seems to be the sparing effect on my liver. So far, so good. I'm on several other meds, like prednisone (boy, I'd like to get off that) and Plaquenil (great help)and pain meds too.
If you need the MTX, the injections seem the way to go to reduce side effects and get "more bang for your buck" towards the RA.
Steve
09 Nov 2009, 04:52
When I started taking Methotrexate for Psoriatic Arthritis - the doctor started me on pills to determine my tolerance - then switched to liquid injections - 1ml/weekly. He stated the reason for the injections was liver damage - that in pill format, 100% is processed by the liver - in the liquid injectable format, 20% is processed by the liver.

The self injections were easy - be sure to use a thin needle - the thing I did not like were the monthly blood tests.

Best to Everyone.
sharon turner
09 Nov 2009, 02:59
hi all, i have been on methotrexate for my psoriatic arthritis for 1o months orally. changed to injection form 4 weeks ago but i still have the nausea and fatigue. i take folic acid 6 days out of 7 but do not think it makes any difference. get joint injections to help relieve swelling and pain, going tomorrow for one into my ankle. not looking forward to it.
Brenda
06 Nov 2009, 11:52
I started injection of the methotrexate instead of 6 pills what a difference it has made. I no longer hate for sunday to come and the 3-4 days that follow with the side effects.I was at first scared as I do not like needles but its very easy and pain free. I highly suggest to talk with your doctor about changing if you have side effects with the pills. good luck
kristy
05 Nov 2009, 18:53
My experience with methotrexate is good its a miracle drug in my book but im not so keen on the idea of the needle , I also have a hard time remembering to take my folic acid , how dangerous is this ?
Linda
29 Oct 2009, 13:47
I have been on Methotrexate for about 3 months. The shot once a week. I have been walking with a cane for about 7 years because of my mobility. since I have I been on the shot I had not to use my cane, for that I am greatful. But I notice my appetite has change and losing weight, I take a bite of two and can't eat any more. I am finding that I am Nausea, and some stomach cramping. Is this a side affect. I was told that this medicine was use with Cancer patient. How true is this.
Lisa McCulloch
21 Oct 2009, 14:18
Hi Everyone,
I've been taking Methotrexate ( 10 tablets) for about 12 years. A few months ago I started to get really really bad stomach pains and headaches. Taking them on Saturday really wiped out the weekend which at 26 is not the greatest thing. (Or any age :) I asked if it would be possible for me to try the injection. I'm going for my first one tomorrow morning. It gonna mess up my 'tablet' day but hey ho it's worth a go. Reading this i'm starting to feel a bit nervous now. :S I'll write back soon and compare stories.
Take care everyone,
Lisa.xx
Kevin Southall
13 Oct 2009, 03:42
Hello, I have been on injection form for only a few weeks but have noticed more hair loss when washing than normal also my hair on top seems to becoming realy fine and I am worried about losing my hair anyway, is this normal ? will it stop or should I stop the injections can anyone advise me. Thanks.
Carol
30 Sep 2009, 16:42
I have taken MTX injections for 10 yrs. I was unable to tolerate the folic acid. I tried everything but would end up with heartburn & indigestion. ( This is what I experienced when I was pregnant, also. So, I don't take folic acid)
Cynthia
25 Sep 2009, 14:12
My doctor has not officially said I have RA but some type of Arthritis. She currently has me on 8 tab of methotrexate and I am so far lucky not to experience any side effects but I am not experiencing any relief either. She has also added a daily does of Plaquinel and I have not noticed any improvement. She has mentioned switching me to the injection. I am wondering if I can expect better results.... Is it possible to respond to injection form and not the tablet form?
chris bardy
20 Sep 2009, 13:31
Hi
In reply to a question i have been put on injection from tabs cos of tummy pain nd headaches on my second week now nd still the same So wot do you do
Chris
Linda Sercombe
01 Sep 2009, 07:16
I have just recently been changed from tabs to injections because of the need to increase the doseage and associated side effects i suffer but after the third weekly injection my imflamation levels have gone up and my joints, feet and hands have becombe swollen and painful as if i had stop taken methotexate completely.
is there a delay period when you change from tabs to injections?
has anyone else had a similar adverse reaction?
lidia
22 Aug 2009, 11:57
is there anyone else also taking placquenil for the fatigue from RA i am injecting once a week of methotrexate, and always nauseous and am taking folic acid everyday. humira and enbrel were to painful for me
Georgette
04 Aug 2009, 13:01
Hi ive been taking injection methotrexate for 8 weeks now, but every timei have an injection i get around red rash almost like a heat rash approximately 1 week after havingthe injection. Has any one else experienced this,if so will the rash ease off. i am still waitingnfor the injection to start workingalthough i hardly get any sicky feelings at all.
andy whiteside
24 Jul 2009, 08:23
Hi. I have recently been diagnosed with disorder and was put on methotrexate, 8 tabs once a week due to side effects which included upset tummy feeling sick and horrible headaches which would last for nearly 2 days, i have now been taken off the tabs and about to start on injection and am worried that i am going to suffer the same reactions. Can anyone who has been through this ease my mind as to whether the injection is better than tabs.
Andy
Pam
20 Jun 2009, 19:22
I've been on methotrexate now for about 8 months. I was taking 5 pills then increased it to 7 a week. Still too much pain in joints and stomach pain was pretty bad. Now I on injections once a week now for the last 2 weeks. I haven't noticed and change yet but my RA doctor said it would take about 4 weeks to notice the difference. Still get flares in my feet, hands and wrists but nothing like it was before taking methotrexate. I was unable to function before the medication.
barbara
13 Jun 2009, 23:41
I'm fairly new to this illness called rheumatoid arthritis, and I can't say I really like it much. I'm embarrassed to ask others to open a jar of pickles or my coffee creamer. I take methotrexate (15 grams) every week, and it really helps. I'm having shoulder surgery soon, and i had to stop taking it - this week is BAD. And once I stop my work for the day, I just want to fall asleep! Is that normal? Thanks so much for listening. Bless everyone suffering with this miserable disease.
Jane
12 Jun 2009, 11:17
I've been taking METH for several years now -currently 6 tabs per week. It's the highest dose I can take without awful side effects (headache, tired, sick, nauseated) that go on for two days. My rheumatologist finally said to break up the dose so now I take 3 pills before bed, then 3 pills again before bed the following night (all in 24 hours). This has helped quite a bit.

ALSO, he gave me folic acid Rx, but that didn't help at all. Another doctor said 40% of people in US don't have the gene allowing our bodies to process prescription folic acid. This doctor put me on a methylated or water soluable folic acid. BINGO. Life has gotten much better the last several weeks.
julie
07 Jun 2009, 14:27
hi christa, in reply to your concern about the side effects of methetrexate, do you have you regular blood monitoring? it is very important, and not to take any over the counter medicines without the advice of your r nurse or doc..

julie liverpool.. if you would like to email me i can send you some info on natural therapy products..
julie
07 Jun 2009, 14:21
i take meth orally every time i take it once a week the day after i get very giddy, and just feel awful. also my rhymatoligist just said take one follic acid once a week, some people i see take it every day. is this right?
Christa
12 May 2009, 04:54
I'm taking Methotrexate oral pill. I'm taking 2.5 mg (4 tab) weekly. After I take it I seem to feel fatique and a little achy. Is this normal?
I'm also concern about the side affect of this medication. I heard it can affect your liver and immune system. I did take Prednisone and it upset my stomach I just stop and gosh I felt miserable. Now I'm on Methotrexate seem to help with the swelling and pain. I just concern about the side effect of this medication. Anyone else who is condern about this medication.
Denise Huang
16 Apr 2009, 15:11
My rheumotologist gave me Euflexxa injections for my OA in both knees. He said this new medication just like to add a new "cushion" between bones in my joints. Since I am allergic to many medications and had a history of ulcer in my stomach, this new treatment may prevent from further health problems.

I can't find any information about Euflexxa in your website. Please let me know the detail of this new product. Thnak you.
Nan in Waco
13 Apr 2009, 12:32
Now that I inject methotrexate rather than take it orally, I experience no stomach irritation. It was getting so that my stomach would hurt for a day or two after taking the oral dose. Keep in mind, I'm referring to actual stomach pain rather than nausea. Daily folic acid, keeping well rested, staying hydrated and not letting your stomach get empty are ways to help reduce nausea.
Janice Sweat
31 Mar 2009, 18:15
My experience with methotrexate pills vs injections bears out the truth of this article. I experience extremely better results when I inject methotrexate once a week versus taking the pills.
Doctors should be more forthcoming with their patients re this. My doctor didn't tell me anything about the difference.
Maybe he didn't know.

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