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Probenecid and colchicine


Drug Class:

Uric acid drugs (Uricosuric)



One pill (500 mg probenecid and 0.5 mg colchicine) twice a day.

Potential Side Effects


Anemia; diarrhea; dizziness; fever; flushing; headache; loss of appetite; itching; increase in urination; nausea; rash; sore gums; stomach pain; vomiting.

Special Instructions

  • Do not drink alcohol when taking this medication.
  • Do not take with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Drink plenty of fluids while taking this medication.
  • Take with food or an antacid.

Be Aware


The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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