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Drug Class:

Uric acid drugs (PEGylated uric acid specific enzyme)

Brand Names




8 mg every 2 weeks by IV infusion.

Potential Side Effects


Bruising; constipation; gout flare; infusion reactions during or shortly after treatment (including a change in blood pressure, chest pain, difficulty breathing or hives); nausea; severe allergic reaction; vomiting.

Special Instructions

  • Do not take this drug if you have glucose 6-phosphate dehydrogenase deficiency (G6PD), sometimes called favism. Your doctor may test you for this inherited condition before starting treatment.
  • Gout flares may increase in the first 3 months after starting this drug. Do not stop treatment even if you have more attacks. Your doctor may give you other medications to help manage flares.

Be Aware

  • Before starting pegloticase, tell your doctor if you have heart problems or high blood pressure or if you are planning to get pregnant or breastfeed. Severe allergic reactions are common in people who take this medication and may occur up to 2 hours after the infusion. Your doctor may order corticosteroids and antihistamines prior to treatment to reduce this risk.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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