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Drug Class:

Uric acid drugs (Xanthine oxidase inhibitor)

Brand Names




40 to 80 mg daily. Dose may be adjusted to achieve a blood uric acid level lower than 6 mg/dL.

Potential Side Effects


Gout flares; joint pain; liver function problems; nausea; rash.

Special Instructions

  • Never start or stop this drug during a flare.

Be Aware

  • Do not take febuxostat if you also take azathioprine, mercaptopurine or theophylline. Your doctor may order blood tests to check your liver function while you are taking this medication. Acute gout attacks are common when this drug is started. These attacks may be reduced by gradually increasing the dose and taking an anti-inflammatory medication for the first 6 to 12 months of therapy. The medicine has been linked to a possible increased risk of heart attack and stroke.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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