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Estrogens with progesterone


Drug Class:


Brand Names

Activella, Climara Pro, Premphase, Prempro



Activella, Premphase, Prempro: 0.625 mg daily in a single dose.

Climara Pro: 1 patch daily delivers 0.045 mg estradiol and 0.015 mg levonorgestrel.

Potential Side Effects


Bloating of stomach; breast pain; increased breast size; nausea; swelling of feet and lower legs; weight gain.

Special Instructions

  • Apply patches to clean, dry skin of lower stomach area.
  • Take tablets at the same time each day with a glass of water.

Be Aware

  • Women who have not had a hysterectomy should take estrogen with progesterone. Before taking this drug, talk to your doctor about the possible risk of heart disease, breast or uterine cancer, blood clots and other side effects.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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