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Drug Class:




50 to 150 mg daily in a single dose, taken by mouth. This drug may also be given by intravenous (IV) infusion. IV dosages vary.

Potential Side Effects


Blood in urine; darkening of skin and fingernails; hair loss; infertility; loss of appetite; low blood cell counts; missing menstrual periods; nausea; vomiting.

Special Instructions

  • This drug can cause potential harm to a developing fetus. Use two forms of birth control while taking this drug.
  • Drink plenty of fluids while taking this medication.
  • This drug is very toxic and should be used only for life-threatening organ disease.
  • Take with food.

Be Aware

  • Use of cyclophosphamide may make you more likely to get infections and certain cancers.
  • Your doctor should order periodic blood and urine tests to check for unwanted effects. Before taking any DMARD, tell your doctor if you are planning to become pregnant.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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