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Drug Class:

Biologics (IL-inhibitor)

Brand Names




4 mg/kg injection every 4 weeks.

Potential Side Effects


Diarrhea; headache; upper respiratory infection; pain, redness or swelling at the injection site; stomachache; urinary tract infection.

Be Aware

  • All biologics suppress the immune system and may increase your risk of infections. Tell your doctor if you have an active infection. Do not start treatment if you have a serious or recurrent infection (such as pneumonia). You should be tested for tuberculosis before starting this medication. Do not get a live vaccine when taking biologics.
  • Macrophage activation syndrome (MAS) is a life-threatening disorder that has been reported in some patients with systemic JIA who are taking this drug. MAS symptoms include acute illness with persistent fever, mental status changes, nose and gastrointestinal bleeding, swollen lymph glands, and spleen and liver problems. It requires immediate treatment. This drug should not be taken with TNF inhibitors.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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